Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ANGPT2 - angiopoietin 2
Function
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Involved in the regulation of lymphangiogenesis (PubMed:32908006).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 285 | ENSG00000091879 | ANGPT2 | O15123 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1129 | Pr-39 | 1 | 1 | 15 |
| R-1166 | Pr-39 | 1 | 1 | 12 |
| R-121 | Pr-39 | 1 | 1 | 9 |
| R-1225 | Pr-39 | 1 | 1 | 24 |
| R-1253 | Pr-39 | 1 | 1 | 28 |
| R-1285 | Pr-177 | 1 | 1 | 5 |
| R-1470 | Pr-39 | 1 | 1 | 5 |
| R-1490 | Pr-39 | 1 | 1 | 13 |
| R-1571 | Pr-39 | 1 | 1 | 14 |
| R-1597 | Pr-39 | 1 | 1 | 9 |
| R-1707 | Pr-39 | 1 | 1 | 14 |
| R-1790 | Pr-39 | 1 | 1 | 6 |
| R-1936 | Pr-6 | 1 | 1 | 14 |
| R-2002 | Pr-177 | 1 | 1 | 23 |
| R-2289 | Pr-39 | 1 | 1 | 6 |
| R-2300 | Pr-39 | 1 | 1 | 13 |
| R-2362 | Pr-39 | 1 | 1 | 9 |
| R-2399 | Pr-20 | 1 | 1 | 12 |
| R-2690 | Pr-39 | 1 | 1 | 13 |
| R-2722 | Pr-39 | 1 | 1 | 4 |
| R-2817 | Pr-39 | 1 | 1 | 10 |
| R-2845 | Pr-39 | 1 | 1 | 10 |
| R-2914 | Pr-39 | 1 | 1 | 14 |
| R-2929 | Pr-39 | 1 | 1 | 22 |
| R-2964 | Pr-39 | 1 | 1 | 26 |
| R-3056 | Pr-39 | 1 | 1 | 22 |
| R-3106 | Pr-177 | 1 | 1 | 10 |
| R-3292 | Pr-39 | 1 | 1 | 4 |
| R-3542 | Pr-39 | 1 | 1 | 7 |
| R-3683 | Pr-39 | 1 | 1 | 20 |
| R-3697 | Pr-39 | 1 | 1 | 32 |
| R-426 | Pr-39 | 1 | 1 | 20 |
| R-649 | Pr-6 | 1 | 1 | 13 |
| R-670 | Pr-177 | 1 | 1 | 17 |
| R-702 | Pr-39 | 1 | 1 | 4 |
| R-825 | Pr-39 | 1 | 1 | 9 |
| R-851 | Pr-39 | 1 | 1 | 3 |
| R-892 | Pr-177 | 1 | 1 | 2 |
| R-974 | Pr-39 | 1 | 1 | 5 |