Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ACSL3 - acyl-CoA synthetase long chain family member 3
Function
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 2181 | ENSG00000123983 | ACSL3 | O95573 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1036 | Pr-38 | 1 | 1 | 9 |
| R-1099 | Pr-38 | 1 | 1 | 11 |
| R-1101 | Pr-40 | 1 | 1 | 7 |
| R-1210 | Pr-38 | 1 | 1 | 8 |
| R-1301 | Pr-38 | 1 | 1 | 38 |
| R-1355 | Pr-40 | 1 | 1 | 8 |
| R-1568 | Pr-38 | 1 | 1 | 38 |
| R-159 | Pr-38 | 1 | 1 | 11 |
| R-1590 | Pr-38 | 1 | 1 | 22 |
| R-1611 | Pr-38 | 1 | 1 | 6 |
| R-1736 | Pr-38 | 1 | 1 | 2 |
| R-1830 | Pr-38 | 1 | 1 | 16 |
| R-1873 | Pr-38 | 1 | 1 | 27 |
| R-1875 | Pr-38 | 1 | 1 | 6 |
| R-1884 | Pr-38 | 1 | 1 | 7 |
| R-1938 | Pr-38 | 1 | 1 | 36 |
| R-1944 | Pr-38 | 1 | 1 | 32 |
| R-1950 | Pr-43 | 1 | 1 | 45 |
| R-1967 | Pr-40 | 1 | 1 | 6 |
| R-2021 | Pr-38 | 1 | 1 | 69 |
| R-2032 | Pr-38 | 1 | 1 | 54 |
| R-2159 | Pr-38 | 1 | 1 | 32 |
| R-2427 | Pr-40 | 1 | 1 | 19 |
| R-2453 | Pr-38 | 1 | 1 | 20 |
| R-2499 | Pr-38 | 1 | 1 | 10 |
| R-2655 | Pr-38 | 1 | 1 | 5 |
| R-2670 | Pr-38 | 1 | 1 | 36 |
| R-2685 | Pr-38 | 1 | 1 | 42 |
| R-2756 | Pr-38 | 1 | 1 | 53 |
| R-2768 | Pr-38 | 1 | 1 | 6 |
| R-2801 | Pr-38 | 1 | 1 | 5 |
| R-2807 | Pr-38 | 1 | 1 | 5 |
| R-2828 | Pr-38 | 1 | 1 | 17 |
| R-2908 | Pr-38 | 1 | 1 | 36 |
| R-3386 | Pr-40 | 1 | 1 | 9 |
| R-417 | Pr-40 | 1 | 1 | 14 |
| R-462 | Pr-38 | 1 | 1 | 24 |
| R-767 | Pr-38 | 1 | 1 | 3 |
| R-968 | Pr-38 | 1 | 1 | 22 |
| R-993 | Pr-38 | 1 | 1 | 31 |