Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation THOC2_code_potential_somatic

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-07381	THOC2	up-regulates	NR2E1	activates	R-2391	9	5	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ASK-8007
CMF-07387	THOC2	down-regulates	SATB1	represses	R-1680	24	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB
CMF-07389	THOC2	down-regulates	TNFRSF25	represses	R-2814	2	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE
CMF-07391	THOC2	down-regulates	LHX1	represses	R-2964	17	7	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-07392	THOC2	down-regulates	LHX1	represses	R-2962	17	7	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07393	THOC2	down-regulates	LHX1	represses	R-2963	17	7	Drugs (34) Regulator Drugs (0) Regulon Drugs (34) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, BIRINAPANT, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-07395	THOC2	down-regulates	LHX1	represses	R-2971	17	7	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07399	THOC2	up-regulates	ATF3	activates	R-469	5	2	Drugs (11) Regulator Drugs (0) Regulon Drugs (11) BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB
CMF-07403	THOC2	down-regulates	SOX10	represses	R-3063	8	3	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-07405	THOC2	down-regulates	SOX10	represses	R-3069	8	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07410	THOC2	down-regulates	SIX6	represses	R-3173	4	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB
CMF-07411	THOC2	down-regulates	SIX6	represses	R-3176	4	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, LUCERASTAT
CMF-07412	THOC2	down-regulates	PGR	represses	R-3404	8	2	Drugs (22) Regulator Drugs (21) NORETHINDRONE, ULIPRISTAL ACETATE, ETONOGESTREL, NORGESTREL, DYDROGESTERONE, DESOGESTREL, NORGESTIMATE, PROGESTERONE, HYDROXYPROGESTERONE CAPROATE, MEGESTROL ACETATE, NORELGESTROMIN, ULIPRISTAL, NORETHINDRONE ACETATE, LEVONORGESTREL, ASOPRISNIL, LONAPRISAN, ONAPRISTONE, MEDROXYPROGESTERONE ACETATE, PF-05019702, VILAPRISAN, TELAPRISTONE ACETATE Regulon Drugs (1) TOSEDOSTAT
CMF-07414	THOC2	down-regulates	TFAP2C	represses	R-1340	15	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07415	THOC2	down-regulates	LHX3	represses	R-2002	24	8	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-07416	THOC2	down-regulates	LHX3	represses	R-2011	24	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07417	THOC2	down-regulates	LHX3	represses	R-2016	24	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07420	THOC2	down-regulates	LHX3	represses	R-1996	24	8	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) IMSIDOLIMAB, SPESOLIMAB
CMF-07421	THOC2	down-regulates	LHX3	represses	R-2007	24	8	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) NANGIBOTIDE, CARLUMAB, ENILURACIL, GIMERACIL
CMF-07422	THOC2	down-regulates	LHX3	represses	R-1994	24	8	Drugs (22) Regulator Drugs (0) Regulon Drugs (22) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, PRAMLINTIDE ACETATE, TISOTUMAB VEDOTIN, TOPIRAMATE, VANTICTUMAB, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM, DAVALINTIDE
CMF-07424	THOC2	down-regulates	HOXB13	represses	R-3231	15	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-07428	THOC2	up-regulates	CEBPZ	activates	R-2995	12	3	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TAS0612
CMF-07429	THOC2	up-regulates	CEBPZ	activates	R-2994	12	3	Drugs (33) Regulator Drugs (0) Regulon Drugs (33) SAVOLITINIB, TELISOTUZUMAB VEDOTIN, AMUVATINIB, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, MK-8033, AMG-337, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, JNJ-38877605, GLESATINIB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, GOLVATINIB
CMF-07431	THOC2	up-regulates	RFX2	activates	R-2300	6	1	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-07432	THOC2	up-regulates	IRF3	activates	R-2429	25	4	Drugs (12) Regulator Drugs (0) Regulon Drugs (12) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB
CMF-07433	THOC2	up-regulates	IRF3	activates	R-2446	25	4	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-07434	THOC2	up-regulates	IRF3	activates	R-2437	25	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07440	THOC2	down-regulates	POU4F2	represses	R-2784	13	3	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, DIAZOXIDE, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB
CMF-07441	THOC2	down-regulates	POU4F2	represses	R-2790	13	3	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ASK-8007
CMF-07442	THOC2	down-regulates	LHX5	represses	R-3056	11	2	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB
CMF-07448	THOC2	down-regulates	GATA2	represses	R-1802	4	1	Drugs (14) Regulator Drugs (0) Regulon Drugs (14) GSK-1995057, PRAMLINTIDE, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, SULTHIAME, DORZOLAMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, PRAMLINTIDE ACETATE, TOPIRAMATE, ACETAZOLAMIDE SODIUM, POLMACOXIB, DAVALINTIDE
CMF-07449	THOC2	down-regulates	SCRT1	represses	R-109	4	1	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) CISATRACURIUM, CISATRACURIUM BESYLATE, SUXAMETHONIUM, BRINZOLAMIDE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, MIVACURIUM, SULTHIAME, DORZOLAMIDE, ROCURONIUM BROMIDE, ACETAZOLAMIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, TOPIRAMATE, ACETAZOLAMIDE SODIUM, POLMACOXIB, ROCURONIUM
CMF-07455	THOC2	down-regulates	PAX5	represses	R-352	6	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07457	THOC2	up-regulates	SMAD1	activates	R-1490	21	5	Drugs (18) Regulator Drugs (0) Regulon Drugs (18) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-07465	THOC2	down-regulates	NR0B1	represses	R-2532	3	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB
CMF-35866	THOC2	down-regulates	hsa-mir-7	represses	R-635	18	2	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35867	THOC2	down-regulates	hsa-mir-7	represses	R-1138	18	2	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35868	THOC2	down-regulates	hsa-mir-30d	represses	R-2224	29	13	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35869	THOC2	down-regulates	hsa-mir-30d	represses	R-189	29	13	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-35870	THOC2	down-regulates	hsa-mir-30d	represses	R-2446	29	13	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35871	THOC2	down-regulates	hsa-mir-30d	represses	R-411	29	13	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NI-0801, ELDELUMAB
CMF-35872	THOC2	down-regulates	hsa-mir-30d	represses	R-635	29	13	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35873	THOC2	down-regulates	hsa-mir-30d	represses	R-2849	29	13	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35874	THOC2	down-regulates	hsa-mir-30d	represses	R-983	29	13	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35875	THOC2	down-regulates	hsa-mir-30d	represses	R-1138	29	13	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35876	THOC2	down-regulates	hsa-mir-30d	represses	R-1178	29	13	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35877	THOC2	down-regulates	hsa-mir-30d	represses	R-1234	29	13	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35878	THOC2	down-regulates	hsa-mir-30d	represses	R-1459	29	13	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35879	THOC2	down-regulates	hsa-mir-30d	represses	R-1820	29	13	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35880	THOC2	down-regulates	hsa-mir-30d	represses	R-1916	29	13	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35881	THOC2	down-regulates	hsa-mir-490	represses	R-177	35	13	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35882	THOC2	down-regulates	hsa-mir-490	represses	R-2224	35	13	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35883	THOC2	down-regulates	hsa-mir-490	represses	R-2446	35	13	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35884	THOC2	down-regulates	hsa-mir-490	represses	R-415	35	13	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35885	THOC2	down-regulates	hsa-mir-490	represses	R-679	35	13	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35886	THOC2	down-regulates	hsa-mir-490	represses	R-2837	35	13	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35887	THOC2	down-regulates	hsa-mir-490	represses	R-3013	35	13	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35888	THOC2	down-regulates	hsa-mir-490	represses	R-970	35	13	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35889	THOC2	down-regulates	hsa-mir-490	represses	R-3072	35	13	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) TAS0612, OCRIPLASMIN
CMF-35890	THOC2	down-regulates	hsa-mir-490	represses	R-3459	35	13	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35891	THOC2	down-regulates	hsa-mir-490	represses	R-1459	35	13	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35892	THOC2	down-regulates	hsa-mir-490	represses	R-1645	35	13	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35893	THOC2	down-regulates	hsa-mir-490	represses	R-1820	35	13	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35894	THOC2	down-regulates	hsa-mir-577	represses	R-2202	65	24	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, SATRALIZUMAB, LUCERASTAT
CMF-35895	THOC2	down-regulates	hsa-mir-577	represses	R-177	65	24	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35896	THOC2	down-regulates	hsa-mir-577	represses	R-2224	65	24	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35897	THOC2	down-regulates	hsa-mir-577	represses	R-189	65	24	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-35898	THOC2	down-regulates	hsa-mir-577	represses	R-2446	65	24	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35899	THOC2	down-regulates	hsa-mir-577	represses	R-411	65	24	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NI-0801, ELDELUMAB
CMF-35900	THOC2	down-regulates	hsa-mir-577	represses	R-2465	65	24	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35901	THOC2	down-regulates	hsa-mir-577	represses	R-635	65	24	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35902	THOC2	down-regulates	hsa-mir-577	represses	R-679	65	24	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35903	THOC2	down-regulates	hsa-mir-577	represses	R-2837	65	24	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35904	THOC2	down-regulates	hsa-mir-577	represses	R-2849	65	24	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35905	THOC2	down-regulates	hsa-mir-577	represses	R-970	65	24	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35906	THOC2	down-regulates	hsa-mir-577	represses	R-983	65	24	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35907	THOC2	down-regulates	hsa-mir-577	represses	R-1138	65	24	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35908	THOC2	down-regulates	hsa-mir-577	represses	R-1178	65	24	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35909	THOC2	down-regulates	hsa-mir-577	represses	R-1234	65	24	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35910	THOC2	down-regulates	hsa-mir-577	represses	R-1294	65	24	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, SATRALIZUMAB, LUCERASTAT
CMF-35911	THOC2	down-regulates	hsa-mir-577	represses	R-3459	65	24	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35912	THOC2	down-regulates	hsa-mir-577	represses	R-1459	65	24	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35913	THOC2	down-regulates	hsa-mir-577	represses	R-1510	65	24	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35914	THOC2	down-regulates	hsa-mir-577	represses	R-1645	65	24	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35915	THOC2	down-regulates	hsa-mir-577	represses	R-3707	65	24	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, SATRALIZUMAB, LUCERASTAT
CMF-35916	THOC2	down-regulates	hsa-mir-577	represses	R-1820	65	24	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35917	THOC2	down-regulates	hsa-mir-577	represses	R-1916	65	24	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35918	THOC2	down-regulates	hsa-mir-338	represses	R-177	79	26	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35919	THOC2	down-regulates	hsa-mir-338	represses	R-2224	79	26	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35920	THOC2	down-regulates	hsa-mir-338	represses	R-189	79	26	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-35921	THOC2	down-regulates	hsa-mir-338	represses	R-2446	79	26	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35922	THOC2	down-regulates	hsa-mir-338	represses	R-411	79	26	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NI-0801, ELDELUMAB
CMF-35923	THOC2	down-regulates	hsa-mir-338	represses	R-415	79	26	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35924	THOC2	down-regulates	hsa-mir-338	represses	R-2465	79	26	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35925	THOC2	down-regulates	hsa-mir-338	represses	R-635	79	26	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35926	THOC2	down-regulates	hsa-mir-338	represses	R-679	79	26	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35927	THOC2	down-regulates	hsa-mir-338	represses	R-2837	79	26	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35928	THOC2	down-regulates	hsa-mir-338	represses	R-2849	79	26	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35929	THOC2	down-regulates	hsa-mir-338	represses	R-3013	79	26	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35930	THOC2	down-regulates	hsa-mir-338	represses	R-970	79	26	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35931	THOC2	down-regulates	hsa-mir-338	represses	R-983	79	26	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35932	THOC2	down-regulates	hsa-mir-338	represses	R-3072	79	26	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) TAS0612, OCRIPLASMIN
CMF-35933	THOC2	down-regulates	hsa-mir-338	represses	R-1138	79	26	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35934	THOC2	down-regulates	hsa-mir-338	represses	R-1178	79	26	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35935	THOC2	down-regulates	hsa-mir-338	represses	R-3231	79	26	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35936	THOC2	down-regulates	hsa-mir-338	represses	R-1234	79	26	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35937	THOC2	down-regulates	hsa-mir-338	represses	R-1294	79	26	Drugs (5) Regulator Drugs (0) Regulon Drugs (5) ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, SATRALIZUMAB, LUCERASTAT
CMF-35938	THOC2	down-regulates	hsa-mir-338	represses	R-3459	79	26	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35939	THOC2	down-regulates	hsa-mir-338	represses	R-1459	79	26	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35940	THOC2	down-regulates	hsa-mir-338	represses	R-1510	79	26	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR
CMF-35941	THOC2	down-regulates	hsa-mir-338	represses	R-1645	79	26	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-35942	THOC2	down-regulates	hsa-mir-338	represses	R-1820	79	26	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-35943	THOC2	down-regulates	hsa-mir-338	represses	R-2016	79	26	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)

Causal Mechanistic Flows regulated by Mutation THOC2_code_potential_somatic

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