Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation REPIN1_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-28197 | REPIN1 | up-regulates | REST | represses | R-464 | 5 | 2 | Drugs (26) Regulator Drugs (0)Regulon Drugs (26)ACAMPROSATE CALCIUM, AV-101, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, MEMANTINE HYDROCHLORIDE, ORPHENADRINE HYDROCHLORIDE, NERAMEXANE, KETAMINE, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, ORPHENADRINE, FELBAMATE, AMANTADINE HYDROCHLORIDE, RAPASTINEL, LANICEMINE, ACAMPROSATE, RALFINAMIDE, GW468816, NERAMEXANE MESYLATE, ORPHENADRINE CITRATE, APIMOSTINEL, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, KETAMINE HYDROCHLORIDE |
| CMF-28198 | REPIN1 | up-regulates | STAT3 | activates | R-1535 | 25 | 5 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-28199 | REPIN1 | up-regulates | STAT3 | activates | R-1531 | 25 | 5 | Drugs (3) |
| CMF-28205 | REPIN1 | up-regulates | NFKB1 | activates | R-299 | 25 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN |
| CMF-28207 | REPIN1 | up-regulates | ATF3 | activates | R-466 | 5 | 3 | Drugs (4) |
| CMF-28208 | REPIN1 | up-regulates | ATF3 | activates | R-467 | 5 | 3 | Drugs (5) |
| CMF-28211 | REPIN1 | down-regulates | POU4F1 | represses | R-2763 | 11 | 1 | Drugs (1) |
| CMF-28213 | REPIN1 | up-regulates | EGR1 | activates | R-1005 | 20 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28214 | REPIN1 | down-regulates | LHX3 | represses | R-2011 | 24 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28216 | REPIN1 | down-regulates | LHX3 | represses | R-2007 | 24 | 3 | Drugs (4) |
| CMF-28218 | REPIN1 | up-regulates | FOXJ3 | activates | R-1166 | 23 | 3 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-28219 | REPIN1 | up-regulates | FOXJ3 | activates | R-1168 | 23 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-28220 | REPIN1 | down-regulates | NEUROD1 | represses | R-3574 | 5 | 3 | Drugs (3) |
| CMF-28221 | REPIN1 | down-regulates | NEUROD1 | represses | R-3572 | 5 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28222 | REPIN1 | down-regulates | NEUROD1 | represses | R-3571 | 5 | 3 | Drugs (5) |
| CMF-28225 | REPIN1 | down-regulates | PBX1 | represses | R-3162 | 12 | 1 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)SCH-708980, CANAKINUMAB, RILONACEPT, MEDI-5117, GEVOKIZUMAB, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, LUTIKIZUMAB, PF-04236921, GLEMBATUMUMAB VEDOTIN, GLEMBATUMUMAB, SIRUKUMAB, ZILTIVEKIMAB |
| CMF-28228 | REPIN1 | up-regulates | CEBPG | activates | R-1048 | 23 | 3 | Drugs (13) Regulator Drugs (0)Regulon Drugs (13)OPROZOMIB, IXAZOMIB, PENTOXIFYLLINE, CAFFEINE, CITRATED, BORTEZOMIB, ETRUMADENANT, IXAZOMIB CITRATE, CAFFEINE, ADENOSINE, OXTRIPHYLLINE, THEOPHYLLINE, AMINOPHYLLINE, CARFILZOMIB |
| CMF-28230 | REPIN1 | down-regulates | TEF | represses | R-2659 | 15 | 1 | Drugs (2) |
| CMF-28232 | REPIN1 | up-regulates | VDR | activates | R-240 | 14 | 3 | Drugs (3) |
| CMF-28234 | REPIN1 | up-regulates | LTF | activates | R-3602 | 2 | 1 | Drugs (1) |
| CMF-28235 | REPIN1 | up-regulates | FOXO3 | activates | R-752 | 24 | 1 | Drugs (1) |
| CMF-28236 | REPIN1 | up-regulates | CEBPB | activates | R-1309 | 23 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)SUTIMLIMAB, NANGIBOTIDE, CARLUMAB, HUMAN C1-ESTERASE INHIBITOR, ENILURACIL, GIMERACIL |
| CMF-28238 | REPIN1 | up-regulates | CEBPB | activates | R-1314 | 23 | 3 | Drugs (1) |
| CMF-28240 | REPIN1 | down-regulates | NFIX | represses | R-1330 | 9 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28243 | REPIN1 | down-regulates | TRAF4 | represses | R-2271 | 14 | 4 | Drugs (2) |
| CMF-28244 | REPIN1 | down-regulates | TRAF4 | activates | R-2273 | 14 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28245 | REPIN1 | up-regulates | BACH1 | activates | R-2754 | 11 | 1 | Drugs (1) |
| CMF-28247 | REPIN1 | down-regulates | NKX2-2 | represses | R-3293 | 17 | 2 | Drugs (4) |
| CMF-42581 | REPIN1 | down-regulates | hsa-mir-186 | represses | R-2402 | 10 | 2 | Drugs (1) |
| CMF-42582 | REPIN1 | down-regulates | hsa-mir-186 | represses | R-2837 | 10 | 2 | Drugs (1) |