Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation PRKDC_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-30133 | PRKDC | up-regulates | TRIM28 | activates | R-763 | 7 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)RO-6870810, MOLIBRESIB, BIRABRESIB, BMS-986158, CPI-0610, APABETALONE |
| CMF-30136 | PRKDC | down-regulates | POU4F1 | represses | R-2759 | 11 | 1 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, DIAZOXIDE, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-30137 | PRKDC | up-regulates | RUNX3 | activates | R-201 | 11 | 1 | Drugs (1) |
| CMF-43182 | PRKDC | down-regulates | hsa-mir-346 | represses | R-2123 | 20 | 16 | Drugs (1) |
| CMF-43183 | PRKDC | down-regulates | hsa-mir-346 | represses | R-117 | 20 | 16 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-43184 | PRKDC | down-regulates | hsa-mir-346 | represses | R-2412 | 20 | 16 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-43185 | PRKDC | down-regulates | hsa-mir-346 | represses | R-397 | 20 | 16 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-43186 | PRKDC | down-regulates | hsa-mir-346 | represses | R-419 | 20 | 16 | Drugs (2) |
| CMF-43187 | PRKDC | down-regulates | hsa-mir-346 | represses | R-2477 | 20 | 16 | Drugs (2) |
| CMF-43188 | PRKDC | down-regulates | hsa-mir-346 | represses | R-2481 | 20 | 16 | Drugs (1) |
| CMF-43189 | PRKDC | down-regulates | hsa-mir-346 | represses | R-2585 | 20 | 16 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-43190 | PRKDC | down-regulates | hsa-mir-346 | represses | R-2767 | 20 | 16 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-43191 | PRKDC | down-regulates | hsa-mir-346 | represses | R-2885 | 20 | 16 | Drugs (1) |
| CMF-43192 | PRKDC | down-regulates | hsa-mir-346 | represses | R-3134 | 20 | 16 | Drugs (1) |
| CMF-43193 | PRKDC | down-regulates | hsa-mir-346 | represses | R-3348 | 20 | 16 | Drugs (1) |
| CMF-43194 | PRKDC | down-regulates | hsa-mir-346 | represses | R-1592 | 20 | 16 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-43195 | PRKDC | down-regulates | hsa-mir-346 | represses | R-1679 | 20 | 16 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-43196 | PRKDC | down-regulates | hsa-mir-346 | represses | R-1829 | 20 | 16 | Drugs (2) |
| CMF-43197 | PRKDC | down-regulates | hsa-mir-346 | represses | R-1926 | 20 | 16 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-43198 | PRKDC | down-regulates | hsa-mir-328 | represses | R-2481 | 27 | 1 | Drugs (1) |
| CMF-43199 | PRKDC | down-regulates | hsa-mir-30d | represses | R-2446 | 29 | 3 | Drugs (1) |
| CMF-43200 | PRKDC | down-regulates | hsa-mir-30d | represses | R-1459 | 29 | 3 | Drugs (1) |
| CMF-43201 | PRKDC | down-regulates | hsa-mir-30d | represses | R-1820 | 29 | 3 | Drugs (1) |