Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation NRXN1_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-13718 | NRXN1 | down-regulates | POU4F1 | represses | R-2758 | 11 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13719 | NRXN1 | down-regulates | TAL1 | represses | R-322 | 11 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13720 | NRXN1 | down-regulates | RFX3 | represses | R-3152 | 3 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, CINTREDEKIN BESUDOTOX, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-37650 | NRXN1 | down-regulates | hsa-mir-551b | represses | R-572 | 22 | 3 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, BHQ-880, ABITUZUMAB |
| CMF-37651 | NRXN1 | down-regulates | hsa-mir-551b | represses | R-646 | 22 | 3 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)ALEPLASININ, SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, BHQ-880, VESENCUMAB, ABITUZUMAB |
| CMF-37652 | NRXN1 | down-regulates | hsa-mir-551b | represses | R-3010 | 22 | 3 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)SULTHIAME, CILENGITIDE, SENICAPOC, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, ABITUZUMAB |
| CMF-37653 | NRXN1 | down-regulates | hsa-mir-95 | represses | R-3604 | 73 | 1 | Drugs (1) |
| CMF-37654 | NRXN1 | down-regulates | hsa-mir-93 | represses | R-378 | 44 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)DINOPROSTONE, BRODALUMAB, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-37655 | NRXN1 | down-regulates | hsa-mir-93 | represses | R-998 | 44 | 2 | Drugs (5) |
| CMF-37656 | NRXN1 | down-regulates | hsa-mir-20b | represses | R-378 | 44 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)DINOPROSTONE, BRODALUMAB, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-37657 | NRXN1 | down-regulates | hsa-mir-20b | represses | R-998 | 44 | 2 | Drugs (5) |