Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation NR1H4_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-28863 | NR1H4 | down-regulates | TEAD1 | represses | R-2400 | 15 | 1 | Drugs (2) |
| CMF-28878 | NR1H4 | down-regulates | POU4F1 | activates | R-2757 | 11 | 2 | Drugs (2) |
| CMF-28881 | NR1H4 | down-regulates | SOX5 | represses | R-259 | 18 | 5 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-28884 | NR1H4 | down-regulates | SOX5 | represses | R-274 | 18 | 5 | Drugs (2) |
| CMF-28887 | NR1H4 | up-regulates | ARID5A | activates | R-171 | 15 | 2 | Drugs (2) |
| CMF-28893 | NR1H4 | down-regulates | PBX1 | represses | R-3161 | 12 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-28895 | NR1H4 | up-regulates | NFE2L2 | activates | R-1379 | 10 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28905 | NR1H4 | down-regulates | SOX2 | represses | R-2687 | 16 | 2 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-28906 | NR1H4 | up-regulates | LTF | represses | R-3601 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28909 | NR1H4 | down-regulates | FOXO3 | represses | R-737 | 24 | 7 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-28916 | NR1H4 | up-regulates | CEBPB | activates | R-1300 | 23 | 2 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-28917 | NR1H4 | up-regulates | CEBPB | activates | R-1309 | 23 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)SUTIMLIMAB, NANGIBOTIDE, CARLUMAB, HUMAN C1-ESTERASE INHIBITOR, ENILURACIL, GIMERACIL |
| CMF-28918 | NR1H4 | down-regulates | NR2C2 | represses | R-3509 | 3 | 2 | Drugs (2) |