Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation MUC2_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00784 | MUC2 | down-regulates | TEAD1 | activates | R-2395 | 15 | 3 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-00790 | MUC2 | down-regulates | MTF1 | activates | R-983 | 23 | 8 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-00794 | MUC2 | down-regulates | LHX2 | activates | R-3707 | 7 | 2 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)ELIGLUSTAT, ELIGLUSTAT TARTRATE, MIGLUSTAT, SATRALIZUMAB, LUCERASTAT |
| CMF-00799 | MUC2 | down-regulates | SATB1 | activates | R-1693 | 24 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00800 | MUC2 | down-regulates | SATB1 | activates | R-1682 | 24 | 7 | Drugs (2) |
| CMF-00801 | MUC2 | down-regulates | SATB1 | activates | R-1694 | 24 | 7 | Drugs (1) |
| CMF-00832 | MUC2 | down-regulates | SP4 | activates | R-2352 | 8 | 2 | Drugs (13) Regulator Drugs (0)Regulon Drugs (13)CE-224535, TERODILINE, GSK1482160, E-6201, GABAPENTIN ENACARBIL, PREGABALIN, ATAGABALIN, GABAPENTIN, BEPRIDIL, SULOCTIDIL, IMAGABALIN, AZD9056, JNJ-54175446 |
| CMF-00841 | MUC2 | down-regulates | PARP1 | activates | R-2372 | 11 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00844 | MUC2 | down-regulates | PARP1 | activates | R-2374 | 11 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00849 | MUC2 | down-regulates | TFCP2L1 | activates | R-2536 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00859 | MUC2 | down-regulates | ETS1 | represses | R-3416 | 3 | 1 | Drugs (2) |
| CMF-00862 | MUC2 | up-regulates | IRF8 | activates | R-411 | 18 | 1 | Drugs (2) |
| CMF-00869 | MUC2 | down-regulates | FOXO3 | represses | R-748 | 24 | 10 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00878 | MUC2 | down-regulates | PKNOX1 | activates | R-2337 | 4 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30941 | MUC2 | down-regulates | LMX1B | represses | R-2929 | 11 | 1 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |