Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation IFT172_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-28482 | IFT172 | down-regulates | FOSL1 | activates | R-1992 | 12 | 1 | Drugs (3) |
| CMF-28483 | IFT172 | up-regulates | NEUROD1 | represses | R-3570 | 5 | 1 | Drugs (1) |
| CMF-28484 | IFT172 | down-regulates | ELF4 | activates | R-3024 | 20 | 2 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-28485 | IFT172 | down-regulates | ELF4 | activates | R-3016 | 20 | 2 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-42683 | IFT172 | up-regulates | hsa-mir-454-3p | represses | R-183 | 31 | 2 | Drugs (4) |
| CMF-42684 | IFT172 | up-regulates | hsa-mir-454-3p | represses | R-2836 | 31 | 2 | Drugs (4) |
| CMF-42685 | IFT172 | up-regulates | hsa-mir-301 | represses | R-2053 | 37 | 7 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-42686 | IFT172 | up-regulates | hsa-mir-301 | represses | R-183 | 37 | 7 | Drugs (4) |
| CMF-42687 | IFT172 | up-regulates | hsa-mir-301 | represses | R-411 | 37 | 7 | Drugs (2) |
| CMF-42688 | IFT172 | up-regulates | hsa-mir-301 | represses | R-2481 | 37 | 7 | Drugs (1) |
| CMF-42689 | IFT172 | up-regulates | hsa-mir-301 | represses | R-646 | 37 | 7 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)ALEPLASININ, SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, BHQ-880, VESENCUMAB, ABITUZUMAB |
| CMF-42690 | IFT172 | up-regulates | hsa-mir-301 | represses | R-2836 | 37 | 7 | Drugs (4) |
| CMF-42691 | IFT172 | up-regulates | hsa-mir-301 | represses | R-1091 | 37 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42692 | IFT172 | up-regulates | hsa-mir-17-3p | represses | R-411 | 52 | 2 | Drugs (2) |
| CMF-42693 | IFT172 | up-regulates | hsa-mir-17-3p | represses | R-1091 | 52 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42694 | IFT172 | up-regulates | hsa-mir-10b | represses | R-411 | 14 | 3 | Drugs (2) |
| CMF-42695 | IFT172 | up-regulates | hsa-mir-10b | represses | R-1091 | 14 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42696 | IFT172 | up-regulates | hsa-mir-10b | represses | R-2053 | 14 | 3 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, TOSEDOSTAT, ACETAZOLAMIDE SODIUM, VESENCUMAB |