Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation FAM83H_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-27665 | FAM83H | down-regulates | VENTX | activates | R-3320 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27666 | FAM83H | up-regulates | SOX12 | represses | R-1100 | 18 | 3 | Drugs (2) |
| CMF-27667 | FAM83H | up-regulates | SOX12 | represses | R-1107 | 18 | 3 | Drugs (4) |
| CMF-27668 | FAM83H | up-regulates | SOX12 | activates | R-1115 | 18 | 3 | Drugs (13) Regulator Drugs (0)Regulon Drugs (13)CE-224535, TERODILINE, GSK1482160, E-6201, GABAPENTIN ENACARBIL, PREGABALIN, ATAGABALIN, GABAPENTIN, BEPRIDIL, SULOCTIDIL, IMAGABALIN, AZD9056, JNJ-54175446 |
| CMF-27669 | FAM83H | up-regulates | KLF13 | represses | R-3156 | 6 | 1 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A |
| CMF-27670 | FAM83H | down-regulates | SREBF1 | activates | R-2507 | 12 | 3 | Drugs (1) |
| CMF-27671 | FAM83H | down-regulates | SREBF1 | activates | R-2503 | 12 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27672 | FAM83H | down-regulates | SREBF1 | activates | R-2498 | 12 | 3 | Drugs (5) |
| CMF-27673 | FAM83H | down-regulates | IRF7 | activates | R-2483 | 21 | 6 | Drugs (4) |
| CMF-27674 | FAM83H | down-regulates | IRF7 | activates | R-2489 | 21 | 6 | Drugs (2) |
| CMF-27675 | FAM83H | down-regulates | IRF7 | activates | R-2482 | 21 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27676 | FAM83H | down-regulates | IRF7 | activates | R-2476 | 21 | 6 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-27677 | FAM83H | down-regulates | IRF7 | activates | R-2478 | 21 | 6 | Drugs (2) |
| CMF-27679 | FAM83H | down-regulates | IRF1 | activates | R-118 | 25 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)DINOPROSTONE, BRODALUMAB, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-27680 | FAM83H | down-regulates | IRF1 | activates | R-114 | 25 | 5 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-27681 | FAM83H | down-regulates | IRF1 | activates | R-123 | 25 | 5 | Drugs (1) |
| CMF-27682 | FAM83H | down-regulates | IRF1 | activates | R-133 | 25 | 5 | Drugs (42) Regulator Drugs (0)Regulon Drugs (42)EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR |
| CMF-27683 | FAM83H | down-regulates | IRF1 | activates | R-115 | 25 | 5 | Drugs (13) Regulator Drugs (0)Regulon Drugs (13)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-27689 | FAM83H | down-regulates | IRF5 | activates | R-1083 | 11 | 3 | Drugs (3) |
| CMF-27690 | FAM83H | down-regulates | IRF5 | activates | R-1091 | 11 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27691 | FAM83H | up-regulates | SP4 | activates | R-2352 | 8 | 4 | Drugs (13) Regulator Drugs (0)Regulon Drugs (13)CE-224535, TERODILINE, GSK1482160, E-6201, GABAPENTIN ENACARBIL, PREGABALIN, ATAGABALIN, GABAPENTIN, BEPRIDIL, SULOCTIDIL, IMAGABALIN, AZD9056, JNJ-54175446 |
| CMF-27692 | FAM83H | up-regulates | SP4 | represses | R-2348 | 8 | 4 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-27695 | FAM83H | up-regulates | SOX5 | represses | R-258 | 18 | 2 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-27696 | FAM83H | up-regulates | SOX5 | represses | R-274 | 18 | 2 | Drugs (2) |
| CMF-27697 | FAM83H | down-regulates | PRRX1 | activates | R-3073 | 18 | 3 | Drugs (3) |
| CMF-27699 | FAM83H | down-regulates | PRRX1 | activates | R-3080 | 18 | 3 | Drugs (2) |
| CMF-27700 | FAM83H | up-regulates | GTF2I | represses | R-3483 | 7 | 1 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, CARFILZOMIB |
| CMF-27701 | FAM83H | down-regulates | GATA6 | activates | R-1258 | 18 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27704 | FAM83H | up-regulates | NF1 | represses | R-2310 | 11 | 5 | Drugs (2) |
| CMF-27705 | FAM83H | up-regulates | NF1 | represses | R-2309 | 11 | 5 | Drugs (1) |
| CMF-27706 | FAM83H | up-regulates | NF1 | represses | R-2305 | 11 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27708 | FAM83H | up-regulates | SOX11 | represses | R-848 | 19 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NATALIZUMAB, FIRATEGRAST, VOLOCIXIMAB, ABITUZUMAB |
| CMF-27710 | FAM83H | up-regulates | MYCN | represses | R-1806 | 5 | 2 | Drugs (2) |
| CMF-27711 | FAM83H | down-regulates | CEBPB | activates | R-1300 | 23 | 5 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)ATN-161, DAVANAT, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-27712 | FAM83H | down-regulates | CEBPB | activates | R-1305 | 23 | 5 | Drugs (5) |
| CMF-27713 | FAM83H | down-regulates | CEBPB | activates | R-1309 | 23 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)SUTIMLIMAB, NANGIBOTIDE, CARLUMAB, HUMAN C1-ESTERASE INHIBITOR, ENILURACIL, GIMERACIL |
| CMF-27714 | FAM83H | down-regulates | CEBPB | activates | R-1321 | 23 | 5 | Drugs (1) |
| CMF-27715 | FAM83H | down-regulates | CEBPB | activates | R-1314 | 23 | 5 | Drugs (1) |
| CMF-27716 | FAM83H | down-regulates | ELF3 | activates | R-3684 | 14 | 3 | Drugs (4) |
| CMF-27717 | FAM83H | down-regulates | ELF3 | activates | R-3695 | 14 | 3 | Drugs (2) |
| CMF-27718 | FAM83H | down-regulates | ELF3 | activates | R-3686 | 14 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27719 | FAM83H | down-regulates | GATA3 | activates | R-3096 | 7 | 5 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-27723 | FAM83H | down-regulates | GATA3 | represses | R-3102 | 7 | 5 | Drugs (5) |
| CMF-27725 | FAM83H | down-regulates | BACH1 | activates | R-2754 | 11 | 4 | Drugs (1) |
| CMF-27726 | FAM83H | down-regulates | BACH1 | activates | R-2748 | 11 | 4 | Drugs (2) |
| CMF-27727 | FAM83H | down-regulates | BACH1 | activates | R-2746 | 11 | 4 | Drugs (3) |
| CMF-27729 | FAM83H | up-regulates | NKX2-2 | represses | R-3293 | 17 | 3 | Drugs (4) |
| CMF-27731 | FAM83H | up-regulates | NKX2-2 | represses | R-3291 | 17 | 3 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)DICHLORPHENAMIDE, SULTHIAME, ACETAZOLAMIDE, ACETAZOLAMIDE SODIUM |
| CMF-42461 | FAM83H | down-regulates | hsa-mir-146b | represses | R-2291 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |