Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation DOCK2_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-23351 | DOCK2 | up-regulates | SHOX2 | activates | R-3542 | 5 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-23353 | DOCK2 | up-regulates | SRF | activates | R-1129 | 18 | 2 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-23354 | DOCK2 | down-regulates | POU4F1 | represses | R-2756 | 11 | 2 | Drugs (2) |
| CMF-23355 | DOCK2 | down-regulates | POU4F1 | represses | R-2760 | 11 | 2 | Drugs (3) |
| CMF-23358 | DOCK2 | up-regulates | JUN | activates | R-216 | 25 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)PICOTAMIDE, TERBOGREL, TD-139, DAVANAT, RAMATROBAN, BELAPECTIN, SERATRODAST, OCRIPLASMIN |
| CMF-23359 | DOCK2 | down-regulates | MNX1 | activates | R-2261 | 4 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23360 | DOCK2 | down-regulates | HOXA11 | represses | R-2738 | 5 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23361 | DOCK2 | down-regulates | HOXA11 | represses | R-2737 | 5 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-41203 | DOCK2 | down-regulates | hsa-mir-139 | represses | R-2459 | 58 | 4 | Drugs (3) |
| CMF-41204 | DOCK2 | down-regulates | hsa-mir-139 | represses | R-2760 | 58 | 4 | Drugs (3) |
| CMF-41205 | DOCK2 | down-regulates | hsa-mir-139 | represses | R-2950 | 58 | 4 | Drugs (3) |
| CMF-41206 | DOCK2 | down-regulates | hsa-mir-139 | represses | R-2006 | 58 | 4 | Drugs (3) |
| CMF-41207 | DOCK2 | down-regulates | hsa-mir-577 | represses | R-2459 | 65 | 4 | Drugs (3) |
| CMF-41208 | DOCK2 | down-regulates | hsa-mir-577 | represses | R-2760 | 65 | 4 | Drugs (3) |
| CMF-41209 | DOCK2 | down-regulates | hsa-mir-577 | represses | R-2950 | 65 | 4 | Drugs (3) |
| CMF-41210 | DOCK2 | down-regulates | hsa-mir-577 | represses | R-2006 | 65 | 4 | Drugs (3) |