Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation CEP250_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-26255 | CEP250 | down-regulates | ATF5 | activates | R-367 | 14 | 3 | Drugs (3) |
| CMF-26257 | CEP250 | down-regulates | IRF1 | activates | R-118 | 25 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)DINOPROSTONE, BRODALUMAB, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-26260 | CEP250 | down-regulates | HLX | activates | R-3580 | 10 | 3 | Drugs (3) |
| CMF-26261 | CEP250 | down-regulates | HLX | activates | R-3582 | 10 | 3 | Drugs (4) |
| CMF-26263 | CEP250 | down-regulates | ARID5A | activates | R-162 | 15 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-26264 | CEP250 | down-regulates | ARID5A | activates | R-165 | 15 | 3 | Drugs (5) |
| CMF-26265 | CEP250 | down-regulates | GATA6 | activates | R-1256 | 18 | 3 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)MEDI-8968, ANAKINRA, AMG-108, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CMF-26270 | CEP250 | up-regulates | SOX21 | represses | R-3568 | 9 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26271 | CEP250 | down-regulates | PRDM1 | activates | R-153 | 21 | 7 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, MIFAMURTIDE, PEFCALCITOL, LUNACALCIPOL, TOSEDOSTAT, DP001, ALFACALCIDOL |
| CMF-26272 | CEP250 | down-regulates | PRDM1 | activates | R-156 | 21 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TROXACITABINE, CLOFARABINE, CYTARABINE, GEMCITABINE HYDROCHLORIDE, GEMCITABINE, ASPACYTARABINE, FLUDARABINE PHOSPHATE |
| CMF-26274 | CEP250 | down-regulates | PRDM1 | activates | R-146 | 21 | 7 | Drugs (3) |
| CMF-26275 | CEP250 | down-regulates | PRDM1 | activates | R-152 | 21 | 7 | Drugs (1) |
| CMF-26276 | CEP250 | down-regulates | PRDM1 | activates | R-145 | 21 | 7 | Drugs (5) |
| CMF-26279 | CEP250 | down-regulates | VDR | activates | R-240 | 14 | 3 | Drugs (3) |
| CMF-26281 | CEP250 | down-regulates | CEBPB | activates | R-1305 | 23 | 2 | Drugs (5) |