Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
CD44 - CD44 molecule (Indian blood group)
Function
Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 960 | ENSG00000026508 | CD44 | P16070 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-141 | Pr-172 | 1 | 1 | 6 |
| R-1447 | Pr-22 | 1 | 1 | 3 |
| R-1459 | Pr-29 | 1 | 1 | 133 |
| R-1680 | Pr-22 | 1 | 1 | 10 |
| R-1768 | Pr-22 | 1 | 1 | 28 |
| R-1820 | Pr-29 | 1 | 1 | 95 |
| R-201 | Pr-29 | 1 | 1 | 3 |
| R-214 | Pr-172 | 1 | 1 | 9 |
| R-2224 | Pr-29 | 1 | 1 | 106 |
| R-2402 | Pr-29 | 1 | 1 | 85 |
| R-2446 | Pr-29 | 1 | 1 | 112 |
| R-2478 | Pr-22 | 1 | 1 | 8 |
| R-2748 | Pr-172 | 1 | 1 | 12 |
| R-2837 | Pr-29 | 1 | 1 | 96 |
| R-2945 | Pr-22 | 1 | 1 | 42 |
| R-3399 | Pr-22 | 1 | 1 | 5 |
| R-3436 | Pr-172 | 1 | 1 | 8 |
| R-3509 | Pr-22 | 1 | 1 | 9 |
| R-440 | Pr-29 | 1 | 1 | 9 |