Regulon

Regulon: R-2499

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
11	2.99261	1	10	Pr-38

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
28951	ENSG00000071575	TRIB2	Q92519
2181	ENSG00000123983	ACSL3	O95573
643314	ENSG00000127603	MACF1	B4DQX9
9805	ENSG00000136193	SCRN1	Q12765
5868	ENSG00000144566	RAB5A	P20339
56999	ENSG00000163638	ADAMTS9	Q9P2N4
10252	ENSG00000164056	SPRY1	O43609
9435	ENSG00000175040	CHST2	Q9Y4C5
3556	ENSG00000196083	IL1RAP	Q9NPH3
3269	ENSG00000196639	HRH1	P35367
2119	ENSG00000244405	ETV5	P41161

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase
PROMETHAZINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TRIPROLIDINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
LEVOCETIRIZINE DIHYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
KETOTIFEN FUMARATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
PYRILAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TRIPELENNAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
RUPATADINE	PTAFR	Small molecule	ANTAGONIST	Platelet activating factor receptor antagonist	3
DOXYLAMINE SUCCINATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
MECLIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BEPOTASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BROMPHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CLEMASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
OLOPATADINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CYPROHEPTADINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
EPINASTINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TERFENADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CARBINOXAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DEXCHLORPHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ORPHENADRINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4
CHLORPHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
IMSIDOLIMAB	IL1RL2	Antibody	ANTAGONIST	IL36 receptor antagonist	2
DEXBROMPHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
OLOPATADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ASTEMIZOLE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CHLORPHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
HISTAMINE	HRH1	Small molecule	AGONIST	Histamine H1 receptor agonist	4
LEVOCABASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DEXBROMPHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
EBASTINE	HRH1	Small molecule	INVERSE AGONIST	Histamine H1 receptor inverse agonist	3
CINNARIZINE	HRH1	Small molecule	BLOCKER	Voltage-gated L-type calcium channel blocker	4
HYDROXYZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
LORATADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
LY2624803	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	2
PHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TRIPROLIDINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIPHENHYDRAMINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TRIMIPRAMINE	SLC6A2	Small molecule	INHIBITOR	Norepinephrine transporter inhibitor	4
BUCLIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
EPINASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ORPHENADRINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4
KETOTIFEN	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
FEXOFENADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BILASTINE	HRH1	Small molecule	INVERSE AGONIST	Histamine H1 receptor inverse agonist	4
CHLORPHENOXAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
LEVOCABASTINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIBENZEPIN	HRH1	Small molecule	INHIBITOR	Norepinephrine transporter inhibitor	4
PROMETHAZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
AZELASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIPHENHYDRAMINE CITRATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TOLAZOLINE	HRH1	Small molecule	ANTAGONIST	Adrenergic receptor alpha antagonist	4
METHYLPROMAZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
AZELASTINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ANTAZOLINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CYCLIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
FEXOFENADINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DOXYLAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CETIRIZINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIPHENYLPYRALINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ESMIRTAZAPINE MALEATE	ADRA2B	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	3
LEVOCETIRIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ACRIVASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BEPOTASTINE BESYLATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIPHENHYDRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
THENALIDINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIMENHYDRINATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
GSK-1004723	HRH1	Small molecule	ANTAGONIST	Histamine H3 receptor antagonist	2
PYRILAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ORPHENADRINE CITRATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4
DEXCHLORPHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CYPROHEPTADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
PHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CLEMASTINE FUMARATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BROMODIPHENHYDRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIMETHINDENE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
AZATADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ESMIRTAZAPINE	ADRA2B	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	3
BROMPHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
MECLIZINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
METHAPYRILENE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
EMEDASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
MIZOLASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
HYDROXYZINE PAMOATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ALCAFTADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BETAHISTINE	HRH1	Small molecule	AGONIST	Histamine H1 receptor agonist	4
CARBINOXAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DESLORATADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CETIRIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
SPESOLIMAB	IL1RL2	Antibody	ANTAGONIST	IL36 receptor antagonist	3
METHDILAZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-2499

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-04905	ABCC5	down-regulates	SREBF1	activates	R-2499	12	5	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, HYDROXYZINE, LORATADINE, LY2624803, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE
CMF-04993	ODZ4	down-regulates	SREBF1	activates	R-2499	12	3	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, HYDROXYZINE, LORATADINE, LY2624803, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE
CMF-06775	ATRX	down-regulates	SREBF1	activates	R-2499	12	10	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, HYDROXYZINE, LORATADINE, LY2624803, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE
CMF-12921	HTR3E	down-regulates	SREBF1	activates	R-2499	12	6	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, HYDROXYZINE, LORATADINE, LY2624803, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE
CMF-15257	HCN1	up-regulates	SREBF1	activates	R-2499	12	3	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, HYDROXYZINE, LORATADINE, LY2624803, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE
CMF-15362	DSE	up-regulates	SREBF1	activates	R-2499	12	5	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, HYDROXYZINE, LORATADINE, LY2624803, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE
CMF-20297	FREM1	up-regulates	SREBF1	activates	R-2499	12	4	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, HYDROXYZINE, LORATADINE, LY2624803, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE
CMF-22399	IDH1	down-regulates	SREBF1	activates	R-2499	12	10	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, HYDROXYZINE, LORATADINE, LY2624803, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE
CMF-23177	RNF17	up-regulates	SREBF1	activates	R-2499	12	7	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, HYDROXYZINE, LORATADINE, LY2624803, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE
CMF-23676	TP53	down-regulates	SREBF1	activates	R-2499	12	11	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, HYDROXYZINE, LORATADINE, LY2624803, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE

Regulon: R-2499

Regulon Summary

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Causal Mechanistic Flows for Regulon R-2499

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