Regulon

Regulon: R-2342

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
64.0520116Pr-6Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
131566 ENSG00000057019 DCBLD2 Q96PD2
55603 ENSG00000112773 FAM46A Q96IP4
3958 ENSG00000131981 LGALS3 P17931
6574 ENSG00000144136 SLC20A1 Q8WUM9
133 ENSG00000148926 ADM P35318
51129 ENSG00000167772 ANGPTL4 Q9BY76

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
TD-139LGALS3Small moleculeINHIBITORGalectin-3 inhibitor20
DAVANATLGALS3UnknownINHIBITORGalectin-1 inhibitor20
ENIBARCIMABADMAntibodySTABILISERADM stabiliser20
BELAPECTINLGALS3UnknownINHIBITORGalectin-3 inhibitor20

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-2342

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-01660MMRN1down-regulatesNR1H4repressesR-234261Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

TD-139, DAVANAT, ENIBARCIMAB, BELAPECTIN

CMF-05867ZNF813down-regulatesNR1H4repressesR-234261Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

TD-139, DAVANAT, ENIBARCIMAB, BELAPECTIN

CMF-11100ATF7IP2down-regulatesNR1H4repressesR-234263Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

TD-139, DAVANAT, ENIBARCIMAB, BELAPECTIN

CMF-24759CHATdown-regulatesNR1H4repressesR-234261Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

TD-139, DAVANAT, ENIBARCIMAB, BELAPECTIN

CMF-25911MMP13down-regulatesNR1H4repressesR-234261Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

TD-139, DAVANAT, ENIBARCIMAB, BELAPECTIN

CMF-26989HMCN1down-regulatesNR1H4repressesR-234261Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

TD-139, DAVANAT, ENIBARCIMAB, BELAPECTIN