Regulon: R-1638
Regulons
are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.
Regulon Summary
Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio
, its Regulator
, the Transcriptional Program
that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.
Genes | Cox Hazard Ratio | Regulators | Causal Flows | Transcriptional Programs | Hallmarks |
---|---|---|---|---|---|
9 | 2.66598 | 1 | 2 | Pr-137 | ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Regulon Genes
List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator
of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.
Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
---|---|---|---|
30836 | ENSG00000067334 | DNTTIP2 | Q5QJE6 |
5711 | ENSG00000095261 | PSMD5 | F2Z3J2 |
51100 | ENSG00000097033 | SH3GLB1 | Q9Y371 |
5355 | ENSG00000102007 | PLP2 | Q04941 |
23516 | ENSG00000104635 | SLC39A14 | Q15043 |
54793 | ENSG00000104756 | KCTD9 | Q7L273 |
3454 | ENSG00000142166 | IFNAR1 | P17181 |
79071 | ENSG00000170522 | ELOVL6 | Q9H5J4 |
80131 | ENSG00000171017 | LRRC8E | Q6NSJ5 |
Regulon Drugs
Name | Approved Symbol | Type | Action Type | Mechanism of Action | Max Trial Phase | Max GBM Phase |
---|---|---|---|---|---|---|
INTERFERON BETA-1B | IFNAR1 | Protein | AGONIST | Interferon alpha/beta receptor agonist | 4 | 0 |
ANIFROLUMAB | IFNAR1 | Antibody | ANTAGONIST | Interferon-alpha/beta receptor alpha chain antagonist | 4 | 0 |
INTERFERON ALFA-2A | IFNAR1 | Protein | AGONIST | Interferon alpha/beta receptor agonist | 4 | 0 |
INTERFERON ALFA-2B | IFNAR1 | Protein | AGONIST | Interferon alpha/beta receptor agonist | 4 | 0 |
PEGINTERFERON ALFA-2B | IFNAR1 | Protein | AGONIST | Interferon alpha/beta receptor agonist | 4 | 2 |
INTERFERON ALFA-N3 | IFNAR1 | Protein | AGONIST | Interferon alpha/beta receptor agonist | 4 | 0 |
ALBINTERFERON ALFA-2B | IFNAR1 | Protein | AGONIST | Interferon alpha/beta receptor agonist | 3 | 0 |
INTERFERON ALFACON-1 | IFNAR1 | Protein | AGONIST | Interferon alpha/beta receptor agonist | 4 | 0 |
ROPEGINTERFERON ALFA-2B | IFNAR1 | Unknown | POSITIVE MODULATOR | Interferon alpha/beta receptor positive modulator | 4 | 0 |
PEGINTERFERON ALFA-2A | IFNAR1 | Protein | AGONIST | Interferon alpha/beta receptor agonist | 4 | 2 |
PEGINTERFERON BETA-1A | IFNAR1 | Protein | AGONIST | Interferon alpha/beta receptor agonist | 4 | 0 |
INTERFERON BETA-1A | IFNAR1 | Protein | AGONIST | Interferon alpha/beta receptor agonist | 4 | 0 |
Causal Flows
Causal Flows
are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation
may causally activates or deactivates a downstream regulator
which then might up- or down-regulates a regulon
that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows for Regulon R-1638
ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
---|---|---|---|---|---|---|---|---|
CMF-08947 | ARHGAP32 | down-regulates | ZNF35 | activates | R-1638 | 15 | 1 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
CMF-19745 | BVES | up-regulates | ZNF35 | activates | R-1638 | 15 | 6 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |