Regulon

Regulon: R-1598

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
18	1.98313	1	24	Pr-108

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
9369	ENSG00000021645	NRXN3	Q9HDB5
4345	ENSG00000091972	CD200	F8W7G1
26033	ENSG00000107518	ATRNL1	Q5VV63
79176	ENSG00000107872	FBXL15	Q9H469
7164	ENSG00000111907	TPD52L1	Q16890
3241	ENSG00000115756	HPCAL1	P37235
311	ENSG00000122359	ANXA11	P50995
9467	ENSG00000131370	SH3BP5	O60239
9645	ENSG00000133816	MICAL2	O94851
6775	ENSG00000138378	STAT4	Q14765
9922	ENSG00000144711	IQSEC1	Q6DN90
783	ENSG00000165995	CACNB2	Q08289
5604	ENSG00000169032	MAP2K1	A0A8I5QJL9
25924	ENSG00000170011	MYRIP	Q8NFW9
8534	ENSG00000175264	CHST1	O43916
5464	ENSG00000180817	PPA1	Q15181
2903	ENSG00000183454	GRIN2A	Q12879
29	ENSG00000278741	ABR	Q12979

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
TERODILINE	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
ACAMPROSATE CALCIUM	GABRG2	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4	0
MIRDAMETINIB	MAP2K1	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 1 inhibitor	2	0
AV-101	GRIN1	Small molecule	ANTAGONIST	Glutamate [NMDA] receptor antagonist	2	0
BINIMETINIB	MAP2K2	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 1 inhibitor	4	0
MEMANTINE	GRIN1	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Glutamate [NMDA] receptor negative allosteric modulator	4	2
DEXTROMETHORPHAN HYDROBROMIDE	GRIN2A	Small molecule	AGONIST	Sigma opioid receptor agonist	4	0
COBIMETINIB FUMARATE	MAP2K1	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 2 inhibitor	4	0
RO-4987655	MAP2K2	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 2 inhibitor	1	0
MEMANTINE HYDROCHLORIDE	GRIN1	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Glutamate [NMDA] receptor negative allosteric modulator	4	0
COBIMETINIB	MAP2K1	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 2 inhibitor	4	0
ORPHENADRINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
WX-554	MAP2K1	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 1 inhibitor	1	0
AZD-8330	MAP2K1	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 1 inhibitor	1	0
SELUMETINIB SULFATE	MAP2K2	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor	4	3
PIMASERTIB	MAP2K1	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 1 inhibitor	2	0
SELUMETINIB	MAP2K1	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 2 inhibitor	4	3
NERAMEXANE	GRIN1	Small molecule	ANTAGONIST	Neuronal acetylcholine receptor; alpha9/alpha10 antagonist	3	0
KETAMINE	GRIN1	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Glutamate [NMDA] receptor negative allosteric modulator	4	0
E-6201	MAP2K1	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 1 inhibitor	2	0
DEXTROMETHORPHAN POLISTIREX	GRIN2A	Small molecule	ANTAGONIST	Glutamate [NMDA] receptor subunit epsilon 1 antagonist	4	0
DEXTROMETHORPHAN	GRIN2A	Small molecule	AGONIST	Sigma opioid receptor agonist	4	0
SAMALIZUMAB	CD200	Antibody	INHIBITOR	OX-2 membrane glycoprotein inhibitor	2	0
ORPHENADRINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
TRAMETINIB	MAP2K2	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor	4	1
GABAPENTIN ENACARBIL	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
FELBAMATE	GRIN1	Small molecule	ANTAGONIST	Glutamate [NMDA] receptor antagonist	4	0
AMANTADINE HYDROCHLORIDE	GRIN1	Small molecule	ANTAGONIST	Glutamate [NMDA] receptor antagonist	4	0
PREGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
RAPASTINEL	GRIN1	Protein	PARTIAL AGONIST	Glutamate [NMDA] receptor partial agonist	3	0
ATAGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	2	0
GABAPENTIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
LANICEMINE	GRIN1	Small molecule	BLOCKER	Glutamate [NMDA] receptor blocker	2	0
ACAMPROSATE	GABRG2	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4	0
REFAMETINIB	MAP2K2	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 2 inhibitor	2	0
RALFINAMIDE	MAOB	Small molecule	INHIBITOR	Monoamine oxidase B inhibitor	3	0
BEPRIDIL	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
SULOCTIDIL	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
GW468816	GRIN1	Small molecule	ANTAGONIST	Glutamate [NMDA] receptor antagonist	2	0
NERAMEXANE MESYLATE	GRIN1	Small molecule	ANTAGONIST	Neuronal acetylcholine receptor; alpha9/alpha10 antagonist	3	0
IMAGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	3	0
ORPHENADRINE CITRATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
APIMOSTINEL	GRIN1	Protein	PARTIAL AGONIST	Glutamate [NMDA] receptor partial agonist	2	0
CI-1040	MAP2K1	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 1 inhibitor	2	0
ESKETAMINE	GRIN1	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Glutamate [NMDA] receptor negative allosteric modulator	4	0
INDANTADOL	GRIN1	Small molecule	INHIBITOR	Monoamine oxidase A inhibitor	2	0
ESKETAMINE HYDROCHLORIDE	GRIN1	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Glutamate [NMDA] receptor negative allosteric modulator	4	0
AMANTADINE	GRIN1	Small molecule	ANTAGONIST	Glutamate [NMDA] receptor antagonist	4	0
TRAMETINIB DIMETHYL SULFOXIDE	MAP2K2	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 2 inhibitor	4	0
KETAMINE HYDROCHLORIDE	GRIN1	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Glutamate [NMDA] receptor negative allosteric modulator	4	0
TAK-733	MAP2K1	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 2 inhibitor	1	0
AS-703988	MAP2K1	Small molecule	INHIBITOR	Dual specificity mitogen-activated protein kinase kinase 2 inhibitor	1	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1598

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-02198	OR4N2	up-regulates	TCF3	represses	R-1598	18	2	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-03171	WDR90	up-regulates	TCF3	represses	R-1598	18	3	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-06297	AFF2	up-regulates	TCF3	represses	R-1598	18	5	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-07576	AHNAK2	up-regulates	TCF3	represses	R-1598	18	5	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-15584	SASH1	down-regulates	TCF3	represses	R-1598	18	3	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-17660	DOCK5	up-regulates	TCF3	represses	R-1598	18	2	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-22028	WNT2	up-regulates	TCF3	represses	R-1598	18	2	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-34181	OR4N2	up-regulates	hsa-mir-32	represses	R-1598	1	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-35944	MAG	up-regulates	hsa-mir-181d	represses	R-1598	31	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-36814	RBM47	down-regulates	hsa-mir-636	represses	R-1598	1	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-37150	KCNT1	up-regulates	hsa-mir-32	represses	R-1598	1	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-38036	PTEN	down-regulates	hsa-mir-636	represses	R-1598	1	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-38038	PTEN	down-regulates	hsa-mir-32	represses	R-1598	1	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-38040	PTEN	down-regulates	hsa-mir-641	represses	R-1598	8	2	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-38053	KCNQ5	up-regulates	hsa-mir-32	represses	R-1598	1	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-38070	OR51F1	up-regulates	hsa-mir-181d	represses	R-1598	31	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-38548	TBX5	down-regulates	hsa-mir-636	represses	R-1598	1	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-38555	TBX5	down-regulates	hsa-mir-32	represses	R-1598	1	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-39052	NWD1	up-regulates	hsa-mir-641	represses	R-1598	8	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-39891	IGFN1	up-regulates	hsa-mir-181d	represses	R-1598	31	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-39892	IGFN1	up-regulates	hsa-mir-641	represses	R-1598	8	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-40303	ENPP7	down-regulates	hsa-mir-636	represses	R-1598	1	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-41040	PLAC1L	down-regulates	hsa-mir-636	represses	R-1598	1	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988
CMF-42713	NPHS1	up-regulates	hsa-mir-181d	represses	R-1598	31	1	Drugs (52) Regulator Drugs (0) Regulon Drugs (52) TERODILINE, ACAMPROSATE CALCIUM, MIRDAMETINIB, AV-101, BINIMETINIB, MEMANTINE, DEXTROMETHORPHAN HYDROBROMIDE, COBIMETINIB FUMARATE, RO-4987655, MEMANTINE HYDROCHLORIDE, COBIMETINIB, ORPHENADRINE HYDROCHLORIDE, WX-554, AZD-8330, SELUMETINIB SULFATE, PIMASERTIB, SELUMETINIB, NERAMEXANE, KETAMINE, E-6201, DEXTROMETHORPHAN POLISTIREX, DEXTROMETHORPHAN, SAMALIZUMAB, ORPHENADRINE, TRAMETINIB, GABAPENTIN ENACARBIL, FELBAMATE, AMANTADINE HYDROCHLORIDE, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, LANICEMINE, ACAMPROSATE, REFAMETINIB, RALFINAMIDE, BEPRIDIL, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, ORPHENADRINE CITRATE, APIMOSTINEL, CI-1040, ESKETAMINE, INDANTADOL, ESKETAMINE HYDROCHLORIDE, AMANTADINE, TRAMETINIB DIMETHYL SULFOXIDE, KETAMINE HYDROCHLORIDE, TAK-733, AS-703988

Regulon: R-1598

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