Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
hsa-mir-218 -
Function
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| - | hsa-mir-218 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with hsa-mir-218 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-33853 | TPTE | down-regulates | hsa-mir-218 | represses | R-1459 | 14 | 2 | Drugs (1) |
| CMF-33854 | TPTE | down-regulates | hsa-mir-218 | represses | R-1820 | 14 | 2 | Drugs (1) |
| CMF-35006 | CHAF1A | up-regulates | hsa-mir-218 | represses | R-2224 | 14 | 6 | Drugs (1) |
| CMF-35007 | CHAF1A | up-regulates | hsa-mir-218 | represses | R-2402 | 14 | 6 | Drugs (1) |
| CMF-35008 | CHAF1A | up-regulates | hsa-mir-218 | represses | R-2446 | 14 | 6 | Drugs (1) |
| CMF-35009 | CHAF1A | up-regulates | hsa-mir-218 | represses | R-2830 | 14 | 6 | Drugs (2) |
| CMF-35010 | CHAF1A | up-regulates | hsa-mir-218 | represses | R-2864 | 14 | 6 | Drugs (2) |
| CMF-35011 | CHAF1A | up-regulates | hsa-mir-218 | represses | R-1459 | 14 | 6 | Drugs (1) |
| CMF-36272 | COL17A1 | down-regulates | hsa-mir-218 | represses | R-2402 | 14 | 1 | Drugs (1) |
| CMF-36378 | GPR132 | down-regulates | hsa-mir-218 | represses | R-2402 | 14 | 3 | Drugs (1) |
| CMF-36379 | GPR132 | down-regulates | hsa-mir-218 | represses | R-2446 | 14 | 3 | Drugs (1) |
| CMF-36380 | GPR132 | down-regulates | hsa-mir-218 | represses | R-2837 | 14 | 3 | Drugs (1) |
| CMF-36403 | FLT1 | up-regulates | hsa-mir-218 | represses | R-2446 | 14 | 4 | Drugs (1) |
| CMF-36404 | FLT1 | up-regulates | hsa-mir-218 | represses | R-651 | 14 | 4 | Drugs (2) |
| CMF-36405 | FLT1 | up-regulates | hsa-mir-218 | represses | R-2830 | 14 | 4 | Drugs (2) |
| CMF-36406 | FLT1 | up-regulates | hsa-mir-218 | represses | R-2864 | 14 | 4 | Drugs (2) |
| CMF-36856 | GLIS1 | down-regulates | hsa-mir-218 | represses | R-3180 | 14 | 1 | Drugs (1) |
| CMF-36904 | LRBA | down-regulates | hsa-mir-218 | represses | R-2224 | 14 | 11 | Drugs (1) |
| CMF-36905 | LRBA | down-regulates | hsa-mir-218 | represses | R-2402 | 14 | 11 | Drugs (1) |
| CMF-36906 | LRBA | down-regulates | hsa-mir-218 | represses | R-2426 | 14 | 11 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB |
| CMF-36907 | LRBA | down-regulates | hsa-mir-218 | represses | R-2431 | 14 | 11 | Drugs (2) |
| CMF-36908 | LRBA | down-regulates | hsa-mir-218 | represses | R-2446 | 14 | 11 | Drugs (1) |
| CMF-36909 | LRBA | down-regulates | hsa-mir-218 | represses | R-2451 | 14 | 11 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-36910 | LRBA | down-regulates | hsa-mir-218 | represses | R-651 | 14 | 11 | Drugs (2) |
| CMF-36911 | LRBA | down-regulates | hsa-mir-218 | represses | R-2830 | 14 | 11 | Drugs (2) |
| CMF-36912 | LRBA | down-regulates | hsa-mir-218 | represses | R-2864 | 14 | 11 | Drugs (2) |
| CMF-36913 | LRBA | down-regulates | hsa-mir-218 | represses | R-3033 | 14 | 11 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-36914 | LRBA | down-regulates | hsa-mir-218 | represses | R-3180 | 14 | 11 | Drugs (1) |
| CMF-37047 | NRK | down-regulates | hsa-mir-218 | represses | R-2224 | 14 | 9 | Drugs (1) |
| CMF-37048 | NRK | down-regulates | hsa-mir-218 | represses | R-2402 | 14 | 9 | Drugs (1) |
| CMF-37049 | NRK | down-regulates | hsa-mir-218 | represses | R-2426 | 14 | 9 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB |
| CMF-37050 | NRK | down-regulates | hsa-mir-218 | represses | R-2446 | 14 | 9 | Drugs (1) |
| CMF-37051 | NRK | down-regulates | hsa-mir-218 | represses | R-2451 | 14 | 9 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-37052 | NRK | down-regulates | hsa-mir-218 | represses | R-2837 | 14 | 9 | Drugs (1) |
| CMF-37053 | NRK | down-regulates | hsa-mir-218 | represses | R-3180 | 14 | 9 | Drugs (1) |
| CMF-37054 | NRK | down-regulates | hsa-mir-218 | represses | R-1459 | 14 | 9 | Drugs (1) |
| CMF-37055 | NRK | down-regulates | hsa-mir-218 | represses | R-1820 | 14 | 9 | Drugs (1) |
| CMF-37427 | HTR3E | up-regulates | hsa-mir-218 | represses | R-2224 | 14 | 9 | Drugs (1) |
| CMF-37428 | HTR3E | up-regulates | hsa-mir-218 | represses | R-2402 | 14 | 9 | Drugs (1) |
| CMF-37429 | HTR3E | up-regulates | hsa-mir-218 | represses | R-2426 | 14 | 9 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB |
| CMF-37430 | HTR3E | up-regulates | hsa-mir-218 | represses | R-2446 | 14 | 9 | Drugs (1) |
| CMF-37431 | HTR3E | up-regulates | hsa-mir-218 | represses | R-2451 | 14 | 9 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-37432 | HTR3E | up-regulates | hsa-mir-218 | represses | R-2837 | 14 | 9 | Drugs (1) |
| CMF-37433 | HTR3E | up-regulates | hsa-mir-218 | represses | R-3033 | 14 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-37434 | HTR3E | up-regulates | hsa-mir-218 | represses | R-1459 | 14 | 9 | Drugs (1) |
| CMF-37435 | HTR3E | up-regulates | hsa-mir-218 | represses | R-1820 | 14 | 9 | Drugs (1) |
| CMF-38046 | KCNQ5 | down-regulates | hsa-mir-218 | represses | R-2446 | 14 | 3 | Drugs (1) |
| CMF-38047 | KCNQ5 | down-regulates | hsa-mir-218 | represses | R-2837 | 14 | 3 | Drugs (1) |
| CMF-38048 | KCNQ5 | down-regulates | hsa-mir-218 | represses | R-1459 | 14 | 3 | Drugs (1) |
| CMF-38064 | ERCC6 | up-regulates | hsa-mir-218 | represses | R-2431 | 14 | 5 | Drugs (2) |
| CMF-38065 | ERCC6 | up-regulates | hsa-mir-218 | represses | R-2451 | 14 | 5 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-38066 | ERCC6 | up-regulates | hsa-mir-218 | represses | R-651 | 14 | 5 | Drugs (2) |
| CMF-38067 | ERCC6 | up-regulates | hsa-mir-218 | represses | R-3033 | 14 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38068 | ERCC6 | up-regulates | hsa-mir-218 | represses | R-3180 | 14 | 5 | Drugs (1) |
| CMF-38240 | DCHS2 | down-regulates | hsa-mir-218 | represses | R-2224 | 14 | 10 | Drugs (1) |
| CMF-38241 | DCHS2 | down-regulates | hsa-mir-218 | represses | R-2402 | 14 | 10 | Drugs (1) |
| CMF-38242 | DCHS2 | down-regulates | hsa-mir-218 | represses | R-2431 | 14 | 10 | Drugs (2) |
| CMF-38243 | DCHS2 | down-regulates | hsa-mir-218 | represses | R-2451 | 14 | 10 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-38244 | DCHS2 | down-regulates | hsa-mir-218 | represses | R-651 | 14 | 10 | Drugs (2) |
| CMF-38245 | DCHS2 | down-regulates | hsa-mir-218 | represses | R-2830 | 14 | 10 | Drugs (2) |
| CMF-38246 | DCHS2 | down-regulates | hsa-mir-218 | represses | R-2864 | 14 | 10 | Drugs (2) |
| CMF-38247 | DCHS2 | down-regulates | hsa-mir-218 | represses | R-3033 | 14 | 10 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38248 | DCHS2 | down-regulates | hsa-mir-218 | represses | R-3180 | 14 | 10 | Drugs (1) |
| CMF-38249 | DCHS2 | down-regulates | hsa-mir-218 | represses | R-1459 | 14 | 10 | Drugs (1) |
| CMF-38783 | MAGEA6 | down-regulates | hsa-mir-218 | represses | R-3033 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-41646 | HIST1H2BE | down-regulates | hsa-mir-218 | represses | R-2451 | 14 | 4 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-41647 | HIST1H2BE | down-regulates | hsa-mir-218 | represses | R-3033 | 14 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-41648 | HIST1H2BE | down-regulates | hsa-mir-218 | represses | R-3180 | 14 | 4 | Drugs (1) |
| CMF-41649 | HIST1H2BE | down-regulates | hsa-mir-218 | represses | R-1820 | 14 | 4 | Drugs (1) |
| CMF-42078 | CTNNA2 | down-regulates | hsa-mir-218 | represses | R-2402 | 14 | 5 | Drugs (1) |
| CMF-42079 | CTNNA2 | down-regulates | hsa-mir-218 | represses | R-2426 | 14 | 5 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB |
| CMF-42080 | CTNNA2 | down-regulates | hsa-mir-218 | represses | R-2451 | 14 | 5 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-42081 | CTNNA2 | down-regulates | hsa-mir-218 | represses | R-2837 | 14 | 5 | Drugs (1) |
| CMF-42082 | CTNNA2 | down-regulates | hsa-mir-218 | represses | R-3180 | 14 | 5 | Drugs (1) |
| CMF-42199 | C5AR1 | down-regulates | hsa-mir-218 | represses | R-2426 | 14 | 1 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB |
| CMF-42236 | MYOCD | down-regulates | hsa-mir-218 | represses | R-2451 | 14 | 1 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-42886 | SEMA3E | down-regulates | hsa-mir-218 | represses | R-2402 | 14 | 11 | Drugs (1) |
| CMF-42887 | SEMA3E | down-regulates | hsa-mir-218 | represses | R-2426 | 14 | 11 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB |
| CMF-42888 | SEMA3E | down-regulates | hsa-mir-218 | represses | R-2431 | 14 | 11 | Drugs (2) |
| CMF-42889 | SEMA3E | down-regulates | hsa-mir-218 | represses | R-2446 | 14 | 11 | Drugs (1) |
| CMF-42890 | SEMA3E | down-regulates | hsa-mir-218 | represses | R-2451 | 14 | 11 | Drugs (14) Regulator Drugs (0)Regulon Drugs (14)TAS0612, DASATINIB, LANATOSIDE C, VANDETANIB, TESEVATINIB, DIGOXIN, JI-101, ACETYLDIGITOXIN, TG100-801, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, REGORAFENIB, ISTAROXIME |
| CMF-42891 | SEMA3E | down-regulates | hsa-mir-218 | represses | R-651 | 14 | 11 | Drugs (2) |
| CMF-42892 | SEMA3E | down-regulates | hsa-mir-218 | represses | R-2830 | 14 | 11 | Drugs (2) |
| CMF-42893 | SEMA3E | down-regulates | hsa-mir-218 | represses | R-2864 | 14 | 11 | Drugs (2) |
| CMF-42894 | SEMA3E | down-regulates | hsa-mir-218 | represses | R-3033 | 14 | 11 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-42895 | SEMA3E | down-regulates | hsa-mir-218 | represses | R-3180 | 14 | 11 | Drugs (1) |
| CMF-42896 | SEMA3E | down-regulates | hsa-mir-218 | represses | R-1459 | 14 | 11 | Drugs (1) |
| CMF-43087 | ABCC9 | down-regulates | hsa-mir-218 | represses | R-2224 | 14 | 10 | Drugs (1) |
| CMF-43088 | ABCC9 | down-regulates | hsa-mir-218 | represses | R-2402 | 14 | 10 | Drugs (1) |
| CMF-43089 | ABCC9 | down-regulates | hsa-mir-218 | represses | R-2431 | 14 | 10 | Drugs (2) |
| CMF-43090 | ABCC9 | down-regulates | hsa-mir-218 | represses | R-2446 | 14 | 10 | Drugs (1) |
| CMF-43091 | ABCC9 | down-regulates | hsa-mir-218 | represses | R-651 | 14 | 10 | Drugs (2) |
| CMF-43092 | ABCC9 | down-regulates | hsa-mir-218 | represses | R-2830 | 14 | 10 | Drugs (2) |
| CMF-43093 | ABCC9 | down-regulates | hsa-mir-218 | represses | R-2837 | 14 | 10 | Drugs (1) |
| CMF-43094 | ABCC9 | down-regulates | hsa-mir-218 | represses | R-2864 | 14 | 10 | Drugs (2) |
| CMF-43095 | ABCC9 | down-regulates | hsa-mir-218 | represses | R-1459 | 14 | 10 | Drugs (1) |
| CMF-43096 | ABCC9 | down-regulates | hsa-mir-218 | represses | R-1820 | 14 | 10 | Drugs (1) |