Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
CEBPD - CCAAT enhancer binding protein delta
Function
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 1052 | ENSG00000221869 | CEBPD | P49716 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000221869 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-07130 | ATRX | down-regulates | CEBPD | represses | R-1276 | 10 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22921 | IDH1 | down-regulates | CEBPD | represses | R-1276 | 10 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26969 | TMTC1 | up-regulates | CEBPD | represses | R-1276 | 10 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |