Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
MAFK - MAF bZIP transcription factor K
Function
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9150357, PubMed:8932385). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 7975 | ENSG00000198517 | MAFK | O60675 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000198517 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-06387 | FAT3 | down-regulates | MAFK | represses | R-3329 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09153 | RANBP6 | down-regulates | MAFK | represses | R-3329 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10456 | MYOM2 | up-regulates | MAFK | represses | R-3329 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22195 | PODXL | down-regulates | MAFK | represses | R-3329 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22314 | IDH1 | down-regulates | MAFK | represses | R-3329 | 6 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |