Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
TEAD4 - TEA domain transcription factor 4
Function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 7004 | ENSG00000197905 | TEAD4 | Q15561 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000197905 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01919 | PCDH9 | down-regulates | TEAD4 | activates | R-3366 | 6 | 4 | Drugs (5) |
| CMF-01921 | PCDH9 | down-regulates | TEAD4 | activates | R-3364 | 6 | 4 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-02047 | CNGA4 | up-regulates | TEAD4 | activates | R-3366 | 6 | 1 | Drugs (5) |
| CMF-07814 | TNK2 | down-regulates | TEAD4 | activates | R-3366 | 6 | 2 | Drugs (5) |
| CMF-07815 | TNK2 | down-regulates | TEAD4 | activates | R-3364 | 6 | 2 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-08580 | FOXR2 | down-regulates | TEAD4 | activates | R-3366 | 6 | 3 | Drugs (5) |
| CMF-09250 | RP1 | down-regulates | TEAD4 | activates | R-3366 | 6 | 3 | Drugs (5) |
| CMF-09366 | CUL1 | up-regulates | TEAD4 | activates | R-3367 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14348 | SIPA1L1 | down-regulates | TEAD4 | activates | R-3366 | 6 | 2 | Drugs (5) |
| CMF-14458 | ANKRD33 | up-regulates | TEAD4 | activates | R-3364 | 6 | 1 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-16896 | TIE1 | up-regulates | TEAD4 | activates | R-3366 | 6 | 1 | Drugs (5) |
| CMF-20033 | ARHGEF16 | down-regulates | TEAD4 | activates | R-3366 | 6 | 1 | Drugs (5) |
| CMF-22003 | CARD6 | up-regulates | TEAD4 | activates | R-3367 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28387 | MYO9B | down-regulates | TEAD4 | activates | R-3367 | 6 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30463 | PROKR2 | down-regulates | TEAD4 | activates | R-3366 | 6 | 3 | Drugs (5) |
| CMF-30464 | PROKR2 | down-regulates | TEAD4 | activates | R-3364 | 6 | 3 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-30601 | SALL4 | down-regulates | TEAD4 | activates | R-3366 | 6 | 2 | Drugs (5) |
| CMF-30602 | SALL4 | down-regulates | TEAD4 | activates | R-3364 | 6 | 2 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |