Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

HMGA1 - high mobility group AT-hook 1

Function

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
3159 ENSG00000137309 HMGA1 P17096

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000137309 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-01068ZNF292down-regulatesHMGA1activatesR-1073168Drugs (4)
CMF-01071ZNF292down-regulatesHMGA1activatesR-1068168Drugs (9)
CMF-01072ZNF292down-regulatesHMGA1activatesR-1081168Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-01075ZNF292down-regulatesHMGA1activatesR-1067168Drugs (7)
CMF-05759ADAMTS19down-regulatesHMGA1activatesR-1068161Drugs (9)
CMF-09262RP1down-regulatesHMGA1activatesR-1073164Drugs (4)
CMF-09264RP1down-regulatesHMGA1activatesR-1068164Drugs (9)
CMF-09265RP1down-regulatesHMGA1activatesR-1081164Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-11513OR2T6down-regulatesHMGA1activatesR-1073162Drugs (4)
CMF-11621CHSY3down-regulatesHMGA1activatesR-1081161Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-12027DSC3up-regulatesHMGA1activatesR-1071163Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-17520CNTNAP3down-regulatesHMGA1activatesR-1071162Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-17945PRPF40Bdown-regulatesHMGA1activatesR-1073167Drugs (4)
CMF-17946PRPF40Bdown-regulatesHMGA1activatesR-1071167Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-17948PRPF40Bdown-regulatesHMGA1activatesR-1081167Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-17950PRPF40Bdown-regulatesHMGA1activatesR-1067167Drugs (7)
CMF-20495BCL11Adown-regulatesHMGA1activatesR-1068163Drugs (9)
CMF-21314GRIK3up-regulatesHMGA1activatesR-1071164Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-21317GRIK3up-regulatesHMGA1activatesR-1067164Drugs (7)
CMF-22014MOCS3down-regulatesHMGA1activatesR-1067162Drugs (7)
CMF-24192OR4K5down-regulatesHMGA1activatesR-1081162Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-25862PIK3CAup-regulatesHMGA1activatesR-1081165Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-25864PIK3CAup-regulatesHMGA1activatesR-1067165Drugs (7)