Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
TRIM28 - tripartite motif containing 28
Function
(Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 10155 | ENSG00000130726 | TRIM28 | Q13263 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000130726 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01873 | CYP4F8 | up-regulates | TRIM28 | activates | R-759 | 7 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02858 | SRRM2 | up-regulates | TRIM28 | activates | R-759 | 7 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09991 | OR13C5 | up-regulates | TRIM28 | activates | R-759 | 7 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10905 | BMP5 | up-regulates | TRIM28 | activates | R-759 | 7 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11506 | OR2T6 | down-regulates | TRIM28 | activates | R-763 | 7 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)RO-6870810, MOLIBRESIB, BIRABRESIB, BMS-986158, CPI-0610, APABETALONE |
| CMF-11648 | AHR | up-regulates | TRIM28 | activates | R-759 | 7 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11977 | KRTAP10-11 | up-regulates | TRIM28 | activates | R-759 | 7 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12044 | NOX3 | up-regulates | TRIM28 | activates | R-759 | 7 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16367 | SUSD5 | up-regulates | TRIM28 | activates | R-759 | 7 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17448 | OR5L2 | up-regulates | TRIM28 | activates | R-759 | 7 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-19093 | VPS41 | up-regulates | TRIM28 | activates | R-759 | 7 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21734 | COL1A2 | up-regulates | TRIM28 | activates | R-759 | 7 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21736 | COL1A2 | up-regulates | TRIM28 | activates | R-763 | 7 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)RO-6870810, MOLIBRESIB, BIRABRESIB, BMS-986158, CPI-0610, APABETALONE |
| CMF-25665 | SRGAP1 | up-regulates | TRIM28 | activates | R-759 | 7 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26055 | MST1P9 | up-regulates | TRIM28 | activates | R-763 | 7 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)RO-6870810, MOLIBRESIB, BIRABRESIB, BMS-986158, CPI-0610, APABETALONE |
| CMF-26828 | VAV1 | up-regulates | TRIM28 | activates | R-759 | 7 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29563 | ESRRB | down-regulates | TRIM28 | activates | R-759 | 7 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29566 | ESRRB | down-regulates | TRIM28 | activates | R-763 | 7 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)RO-6870810, MOLIBRESIB, BIRABRESIB, BMS-986158, CPI-0610, APABETALONE |
| CMF-30133 | PRKDC | up-regulates | TRIM28 | activates | R-763 | 7 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)RO-6870810, MOLIBRESIB, BIRABRESIB, BMS-986158, CPI-0610, APABETALONE |