Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
CEBPE - CCAAT enhancer binding protein epsilon
Function
Transcriptional activator (PubMed:26019275). C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 1053 | ENSG00000092067 | CEBPE | Q15744 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000092067 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01901 | CYP4F8 | down-regulates | CEBPE | represses | R-2670 | 13 | 1 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)IMSIDOLIMAB, BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE, SPESOLIMAB |
| CMF-02896 | SRRM2 | down-regulates | CEBPE | represses | R-2670 | 13 | 2 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)IMSIDOLIMAB, BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE, SPESOLIMAB |
| CMF-08835 | FBLN2 | down-regulates | CEBPE | represses | R-2671 | 13 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08838 | FBLN2 | down-regulates | CEBPE | represses | R-2670 | 13 | 4 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)IMSIDOLIMAB, BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE, SPESOLIMAB |
| CMF-09524 | DOCK11 | down-regulates | CEBPE | represses | R-2671 | 13 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09526 | DOCK11 | down-regulates | CEBPE | represses | R-2670 | 13 | 3 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)IMSIDOLIMAB, BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE, SPESOLIMAB |
| CMF-14362 | SIPA1L1 | down-regulates | CEBPE | represses | R-2671 | 13 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16946 | TIE1 | down-regulates | CEBPE | represses | R-2670 | 13 | 1 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)IMSIDOLIMAB, BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE, SPESOLIMAB |
| CMF-24538 | SEMA3C | up-regulates | CEBPE | represses | R-2671 | 13 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24540 | SEMA3C | up-regulates | CEBPE | represses | R-2670 | 13 | 3 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)IMSIDOLIMAB, BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE, SPESOLIMAB |
| CMF-25071 | IQSEC3 | down-regulates | CEBPE | represses | R-2670 | 13 | 5 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)IMSIDOLIMAB, BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE, SPESOLIMAB |
| CMF-25285 | PASD1 | down-regulates | CEBPE | represses | R-2679 | 13 | 3 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN |
| CMF-25468 | PCDHGB3 | down-regulates | CEBPE | represses | R-2671 | 13 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25469 | PCDHGB3 | down-regulates | CEBPE | represses | R-2670 | 13 | 2 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)IMSIDOLIMAB, BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE, SPESOLIMAB |
| CMF-28174 | C1S | down-regulates | CEBPE | represses | R-2670 | 13 | 1 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)IMSIDOLIMAB, BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE, SPESOLIMAB |
| CMF-30589 | C17orf71 | down-regulates | CEBPE | represses | R-2671 | 13 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30590 | C17orf71 | down-regulates | CEBPE | represses | R-2679 | 13 | 2 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN |
| CMF-30836 | RYR1 | down-regulates | CEBPE | represses | R-2671 | 13 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30838 | RYR1 | down-regulates | CEBPE | represses | R-2670 | 13 | 3 | Drugs (5) Regulator Drugs (0)Regulon Drugs (5)IMSIDOLIMAB, BELZUTIFAN, NERAMEXANE, NERAMEXANE MESYLATE, SPESOLIMAB |