Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
HLTF - helicase like transcription factor
Function
Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 6596 | ENSG00000071794 | HLTF | Q14527 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000071794 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-03560 | COL4A6 | up-regulates | HLTF | activates | R-3419 | 4 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03966 | DSP | up-regulates | HLTF | activates | R-3419 | 4 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10346 | FGG | up-regulates | HLTF | activates | R-3419 | 4 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13548 | FMN1 | up-regulates | HLTF | activates | R-3419 | 4 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14777 | ZNF681 | up-regulates | HLTF | activates | R-3419 | 4 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15435 | DSE | up-regulates | HLTF | activates | R-3419 | 4 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27386 | NBPF1 | up-regulates | HLTF | activates | R-3419 | 4 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27473 | SDK1 | up-regulates | HLTF | activates | R-3419 | 4 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |