Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
NFYA - nuclear transcription factor Y subunit alpha
Function
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component BMAL1.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 4800 | ENSG00000001167 | NFYA | P23511 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000001167 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-02200 | OR4N2 | down-regulates | NFYA | activates | R-510 | 11 | 2 | Drugs (5) |
| CMF-08615 | FOXR2 | down-regulates | NFYA | activates | R-510 | 11 | 1 | Drugs (5) |
| CMF-20079 | ARHGEF16 | down-regulates | NFYA | activates | R-510 | 11 | 1 | Drugs (5) |
| CMF-28458 | MYO9B | down-regulates | NFYA | activates | R-510 | 11 | 1 | Drugs (5) |