Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation RSBN1L_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-09130 | RSBN1L | up-regulates | IRF9 | activates | R-1452 | 15 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09131 | RSBN1L | up-regulates | IRF9 | activates | R-1457 | 15 | 2 | Drugs (2) |
| CMF-09135 | RSBN1L | down-regulates | SOX12 | activates | R-1101 | 18 | 4 | Drugs (24) Regulator Drugs (0)Regulon Drugs (24)PAZOPANIB, PEMIGATINIB, BRIVANIB ALANINATE, ERDAFITINIB, HMPL-453, PAZOPANIB HYDROCHLORIDE, BRIVANIB, NINTEDANIB ESYLATE, XL-999, DOVITINIB, ROGARATINIB, AZD-4547, ENMD-2076, INFIGRATINIB, FGFR INHIBITOR DEBIO 1347, INFIGRATINIB PHOSPHATE, NINTEDANIB, FUTIBATINIB, MASITINIB, ORANTINIB, TOSEDOSTAT, DERAZANTINIB, E-7090, ENMD-981693 |
| CMF-09136 | RSBN1L | down-regulates | SOX12 | represses | R-1100 | 18 | 4 | Drugs (2) |
| CMF-09137 | RSBN1L | down-regulates | SOX12 | activates | R-1115 | 18 | 4 | Drugs (13) Regulator Drugs (0)Regulon Drugs (13)CE-224535, TERODILINE, GSK1482160, E-6201, GABAPENTIN ENACARBIL, PREGABALIN, ATAGABALIN, GABAPENTIN, BEPRIDIL, SULOCTIDIL, IMAGABALIN, AZD9056, JNJ-54175446 |
| CMF-09138 | RSBN1L | down-regulates | SOX12 | activates | R-1113 | 18 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09142 | RSBN1L | down-regulates | POU3F1 | represses | R-1660 | 25 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09145 | RSBN1L | down-regulates | PARP1 | activates | R-2371 | 11 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09146 | RSBN1L | down-regulates | POU4F2 | represses | R-2784 | 13 | 1 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, DIAZOXIDE, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-36413 | RSBN1L | down-regulates | hsa-mir-17-3p | represses | R-171 | 52 | 10 | Drugs (2) |
| CMF-36414 | RSBN1L | down-regulates | hsa-mir-17-3p | represses | R-274 | 52 | 10 | Drugs (2) |
| CMF-36415 | RSBN1L | down-regulates | hsa-mir-17-3p | represses | R-307 | 52 | 10 | Drugs (2) |
| CMF-36416 | RSBN1L | down-regulates | hsa-mir-17-3p | represses | R-411 | 52 | 10 | Drugs (2) |
| CMF-36417 | RSBN1L | down-regulates | hsa-mir-17-3p | represses | R-2489 | 52 | 10 | Drugs (2) |
| CMF-36418 | RSBN1L | down-regulates | hsa-mir-17-3p | represses | R-2605 | 52 | 10 | Drugs (2) |
| CMF-36419 | RSBN1L | down-regulates | hsa-mir-17-3p | represses | R-3028 | 52 | 10 | Drugs (2) |
| CMF-36420 | RSBN1L | down-regulates | hsa-mir-17-3p | represses | R-1457 | 52 | 10 | Drugs (2) |
| CMF-36421 | RSBN1L | down-regulates | hsa-mir-17-3p | represses | R-3695 | 52 | 10 | Drugs (2) |
| CMF-36422 | RSBN1L | down-regulates | hsa-mir-17-3p | represses | R-1847 | 52 | 10 | Drugs (2) |