Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation NEB_code_potential_somatic

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-05122NEBup-regulatesATF3activatesR-46651Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

CANAKINUMAB, RILONACEPT, GEVOKIZUMAB, LUTIKIZUMAB

CMF-05123NEBup-regulatesNR3C1activatesR-2049211Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

PRALUZATAMAB RAVTANSINE

CMF-05125NEBup-regulatesELF1activatesR-326243Drugs (124)

Regulator Drugs (0)

Regulon Drugs (124)

PF-04691502, FOSTAMATINIB DISODIUM, PICOTAMIDE, SARGRAMOSTIM, UMBRALISIB, MIDOSTAURIN, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, RUPATADINE, CSL-324, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DASATINIB, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, CCR5MAB004, R-348, AMY-101, LIPEGFILGRASTIM, VICRIVIROC, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, VOBARILIZUMAB, CERDULATINIB, DUVELISIB, CAROTUXIMAB, L19TNFA, APLAVIROC, MARAVIROC, EFALIZUMAB, DACTOLISIB, FILGRASTIM, ZANDELISIB, HMPL-523, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, LERONLIMAB, BALUGRASTIM, SOTRASTAURIN, PILARALISIB, ILORASERTIB, MUPARFOSTAT, PREXIGEBERSEN, TASELISIB, L19SIP 131I, AMG-319, UCN-01, HGS-1025, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, CENICRIVIROC, IDELALISIB, APLAVIROC HYDROCHLORIDE, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, R-333, OTLERTUZUMAB, GUSACITINIB, BI-836826, MAVRILIMUMAB, ERITORAN TETRASODIUM, BMS-813160, PF-04634817, TG100-801, INCB-9471, PEGCETACOPLAN, VICRIVIROC MALEATE, LENOGRASTIM, LIFITEGRAST, DUPILUMAB, ACALISIB, PF-232798, MIVAVOTINIB CITRATE, VELIFLAPON, AZD5672, OCRIPLASMIN, CAL-263, ERITORAN, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, OZAGREL, PA-799, DELCASERTIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, PEGFILGRASTIM, BUPARLISIB, NARATUXIMAB EMTANSINE, GSK-690693, SF-1126, FIBOFLAPON, AL-78898A, ENMD-981693, PANULISIB

CMF-05131NEBdown-regulatesPAX5repressesR-35061Drugs (20)
CMF-05132NEBup-regulatesNFIL3activatesR-367772Drugs (12)
CMF-34850NEBdown-regulateshsa-mir-328repressesR-158275Drugs (110)
CMF-34851NEBdown-regulateshsa-mir-328repressesR-246275Drugs (63)
CMF-34852NEBdown-regulateshsa-mir-328repressesR-257275Drugs (149)

Regulator Drugs (0)

Regulon Drugs (149)

PF-04691502, FOSTAMATINIB DISODIUM, PICOTAMIDE, INFLIXIMAB, UMBRALISIB, MIDOSTAURIN, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, RUPATADINE, HYDROXYCHLOROQUINE, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, PICLIDENOSON, NEMIRALISIB, RP-6530, APITOLISIB, DASATINIB, DS-7423, GSK-2269557, ABATACEPT, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, CCR5MAB004, R-348, AMY-101, PEGSUNERCEPT, GOLIMUMAB, VICRIVIROC, CAFFEINE, CITRATED, MEDI-2338, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, AVE-9633, VOBARILIZUMAB, CERDULATINIB, VESATOLIMOD, DUVELISIB, L19TNFA, APLAVIROC, MARAVIROC, AZD-8848, DACTOLISIB, BOSUTINIB, BAFETINIB, ZANDELISIB, HMPL-523, ETANERCEPT, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, LERONLIMAB, AFELIMOMAB, SOTRASTAURIN, OZORALIZUMAB, PILARALISIB, ILORASERTIB, CERTOLIZUMAB PEGOL, TASELISIB, JNJ-26483327, L19SIP 131I, AMG-319, UCN-01, TADEKINIG ALFA, HYDROXYCHLOROQUINE SULFATE, HGS-1025, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, GEMTUZUMAB, CENICRIVIROC, IDELALISIB, APLAVIROC HYDROCHLORIDE, BELATACEPT, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, CPG-52852, SELGANTOLIMOD, R-333, IMIQUIMOD, GUSACITINIB, REMTOLUMAB, TOLIMIDONE, CAFFEINE, MOTOLIMOD, TOMIVOSERTIB, BMS-813160, GEMTUZUMAB OZOGAMICIN, PF-04634817, TG100-801, INCB-9471, PEGCETACOPLAN, VICRIVIROC MALEATE, ADENOSINE, DUPILUMAB, ACALISIB, PF-232798, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, AZD5672, OCRIPLASMIN, CAL-263, OXTRIPHYLLINE, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, NAMODENOSON, LENIOLISIB, OZAGREL, PA-799, PLACULUMAB, LINTUZUMAB, DELCASERTIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, GSK-690693, THEOPHYLLINE, SF-1126, AMINOPHYLLINE, GSK-1070806, FIBOFLAPON, AL-78898A, ENMD-981693, PANULISIB

CMF-34853NEBdown-regulateshsa-mir-328repressesR-290275Drugs (110)
CMF-34854NEBdown-regulateshsa-mir-328repressesR-356275Drugs (108)
CMF-34855NEBdown-regulateshsa-mir-30drepressesR-86295Drugs (43)
CMF-34856NEBdown-regulateshsa-mir-30drepressesR-192295Drugs (56)
CMF-34857NEBdown-regulateshsa-mir-30drepressesR-232295Drugs (60)
CMF-34858NEBdown-regulateshsa-mir-30drepressesR-275295Drugs (29)
CMF-34859NEBdown-regulateshsa-mir-30drepressesR-350295Drugs (20)
CMF-34860NEBdown-regulateshsa-mir-301repressesR-86377Drugs (43)
CMF-34861NEBdown-regulateshsa-mir-301repressesR-192377Drugs (56)
CMF-34862NEBdown-regulateshsa-mir-301repressesR-232377Drugs (60)
CMF-34863NEBdown-regulateshsa-mir-301repressesR-275377Drugs (29)
CMF-34864NEBdown-regulateshsa-mir-301repressesR-350377Drugs (20)
CMF-34865NEBdown-regulateshsa-mir-301repressesR-2712377Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-34866NEBdown-regulateshsa-mir-301repressesR-896377Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

ALPROSTADIL, DINOPROSTONE, EVATANEPAG, OMIDENEPAG