Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation MYO1A_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-14666 | MYO1A | down-regulates | MTF1 | activates | R-980 | 23 | 1 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-14667 | MYO1A | down-regulates | STAT4 | represses | R-1156 | 16 | 2 | Drugs (1) |
| CMF-14670 | MYO1A | down-regulates | HOXD1 | activates | R-3622 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14673 | MYO1A | up-regulates | POU6F1 | represses | R-3378 | 8 | 2 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-14674 | MYO1A | up-regulates | POU6F1 | represses | R-3379 | 8 | 2 | Drugs (2) |
| CMF-14679 | MYO1A | up-regulates | HOXA7 | activates | R-3762 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14682 | MYO1A | up-regulates | NKX2-2 | represses | R-3291 | 17 | 1 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)DICHLORPHENAMIDE, SULTHIAME, ACETAZOLAMIDE, ACETAZOLAMIDE SODIUM |
| CMF-37917 | MYO1A | up-regulates | hsa-mir-153 | represses | R-2008 | 62 | 1 | Drugs (1) |
| CMF-37918 | MYO1A | up-regulates | hsa-mir-98 | represses | R-3603 | 8 | 1 | Drugs (3) |
| CMF-37919 | MYO1A | up-regulates | hsa-mir-95 | represses | R-2972 | 73 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-37920 | MYO1A | up-regulates | hsa-mir-95 | represses | R-3061 | 73 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-37921 | MYO1A | up-regulates | hsa-mir-95 | represses | R-2008 | 73 | 3 | Drugs (1) |