Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation LILRB1_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-04368 | LILRB1 | down-regulates | PAX1 | represses | R-254 | 3 | 1 | Drugs (29) Regulator Drugs (0)Regulon Drugs (29)RUPATADINE, CSL-324, DASATINIB, LIPEGFILGRASTIM, MEDI-2338, CAROTUXIMAB, BOSUTINIB, BAFETINIB, FILGRASTIM, BALUGRASTIM, ILORASERTIB, JNJ-26483327, TADEKINIG ALFA, PETESICATIB, NEIHULIZUMAB, XL-228, OTLERTUZUMAB, BI-836826, TOLIMIDONE, ERITORAN TETRASODIUM, TG100-801, LENOGRASTIM, OCRIPLASMIN, ERITORAN, PEGFILGRASTIM, NARATUXIMAB EMTANSINE, AMG-557, GSK-1070806, ENMD-981693 |
| CMF-04371 | LILRB1 | up-regulates | IRF8 | activates | R-397 | 18 | 1 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |