Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation DPPA4_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-07658 | DPPA4 | up-regulates | IRF2 | activates | R-419 | 25 | 2 | Drugs (2) |
| CMF-07659 | DPPA4 | up-regulates | VENTX | activates | R-3320 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07661 | DPPA4 | up-regulates | TGIF1 | activates | R-1401 | 9 | 1 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-07662 | DPPA4 | down-regulates | LHX3 | represses | R-2007 | 24 | 1 | Drugs (4) |
| CMF-07663 | DPPA4 | down-regulates | NEUROD1 | represses | R-3574 | 5 | 1 | Drugs (3) |
| CMF-07664 | DPPA4 | up-regulates | WT1 | represses | R-1398 | 4 | 1 | Drugs (2) |
| CMF-36050 | DPPA4 | down-regulates | hsa-mir-19b | represses | R-2953 | 1 | 1 | Drugs (4) |
| CMF-36051 | DPPA4 | down-regulates | hsa-mir-138 | represses | R-171 | 13 | 12 | Drugs (2) |
| CMF-36052 | DPPA4 | down-regulates | hsa-mir-138 | represses | R-189 | 13 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-36053 | DPPA4 | down-regulates | hsa-mir-138 | represses | R-274 | 13 | 12 | Drugs (2) |
| CMF-36054 | DPPA4 | down-regulates | hsa-mir-138 | represses | R-307 | 13 | 12 | Drugs (2) |
| CMF-36055 | DPPA4 | down-regulates | hsa-mir-138 | represses | R-411 | 13 | 12 | Drugs (2) |
| CMF-36056 | DPPA4 | down-regulates | hsa-mir-138 | represses | R-2489 | 13 | 12 | Drugs (2) |
| CMF-36057 | DPPA4 | down-regulates | hsa-mir-138 | represses | R-2605 | 13 | 12 | Drugs (2) |
| CMF-36058 | DPPA4 | down-regulates | hsa-mir-138 | represses | R-3028 | 13 | 12 | Drugs (2) |
| CMF-36059 | DPPA4 | down-regulates | hsa-mir-138 | represses | R-1091 | 13 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-36060 | DPPA4 | down-regulates | hsa-mir-138 | represses | R-1457 | 13 | 12 | Drugs (2) |
| CMF-36061 | DPPA4 | down-regulates | hsa-mir-138 | represses | R-3695 | 13 | 12 | Drugs (2) |
| CMF-36062 | DPPA4 | down-regulates | hsa-mir-138 | represses | R-1847 | 13 | 12 | Drugs (2) |
| CMF-36063 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-2123 | 44 | 22 | Drugs (1) |
| CMF-36064 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-117 | 44 | 22 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-36065 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-171 | 44 | 22 | Drugs (2) |
| CMF-36066 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-189 | 44 | 22 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-36067 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-274 | 44 | 22 | Drugs (2) |
| CMF-36068 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-307 | 44 | 22 | Drugs (2) |
| CMF-36069 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-397 | 44 | 22 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-36070 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-411 | 44 | 22 | Drugs (2) |
| CMF-36071 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-419 | 44 | 22 | Drugs (2) |
| CMF-36072 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-2489 | 44 | 22 | Drugs (2) |
| CMF-36073 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-2585 | 44 | 22 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-36074 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-2605 | 44 | 22 | Drugs (2) |
| CMF-36075 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-3028 | 44 | 22 | Drugs (2) |
| CMF-36076 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-3134 | 44 | 22 | Drugs (1) |
| CMF-36077 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-1091 | 44 | 22 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-36078 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-3348 | 44 | 22 | Drugs (1) |
| CMF-36079 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-1457 | 44 | 22 | Drugs (2) |
| CMF-36080 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-1592 | 44 | 22 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-36081 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-3695 | 44 | 22 | Drugs (2) |
| CMF-36082 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-1679 | 44 | 22 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-36083 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-1847 | 44 | 22 | Drugs (2) |
| CMF-36084 | DPPA4 | down-regulates | hsa-mir-93 | represses | R-1926 | 44 | 22 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |