Regulon

Regulon: R-97

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
412.46075144Pr-7Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
23129 ENSG00000004399 PLXND1 Q9Y4D7
221 ENSG00000006534 ALDH3B1 P43353
695 ENSG00000010671 BTK Q06187
7305 ENSG00000011600 TYROBP O43914
50619 ENSG00000023892 DEF6 Q9H4E7
8635 ENSG00000026297 RNASET2 O00584
3937 ENSG00000043462 LCP2 Q13094
25771 ENSG00000054611 TBC1D22A Q8WUA7
2769 ENSG00000060558 GNA15 K7EP74
64778 ENSG00000075420 FNDC3B Q53EP0
29992 ENSG00000085514 PILRA Q9UKJ1
54209 ENSG00000095970 TREM2 Q9NZC2
51257 ENSG00000099785 2-Mar Q9P0N8
25939 ENSG00000101347 SAMHD1 Q9Y3Z3
11151 ENSG00000102879 CORO1A P31146
951 ENSG00000104894 CD37 P11049
6387 ENSG00000107562 CXCL12 P48061
9450 ENSG00000112799 LY86 O95711
2335 ENSG00000115414 FN1 P02751
56944 ENSG00000116774 OLFML3 Q9NRN5
64747 ENSG00000118855 MFSD1 Q9H3U5
5552 ENSG00000122862 SRGN P10124
55577 ENSG00000124357 NAGK Q9UJ70
9208 ENSG00000124831 LRRFIP1 Q32MZ4
341 ENSG00000130208 APOC1 P02654
4245 ENSG00000131446 MGAT1 P26572
3936 ENSG00000136167 LCP1 P13796
11309 ENSG00000137491 SLCO2B1 A0A1B0GX35
7057 ENSG00000137801 THBS1 P07996
11010 ENSG00000139278 GLIPR1 B4E3S5
23533 ENSG00000141506 PIK3R5 Q8WYR1
1601 ENSG00000153071 DAB2 A0A024R036
6464 ENSG00000160691 SHC1 P29353
7805 ENSG00000162511 LAPTM5 Q13571
1508 ENSG00000164733 CTSB E9PSG5
7096 ENSG00000174125 TLR1 Q15399
391 ENSG00000177105 RHOG Q6ICQ8
9332 ENSG00000177575 CD163 Q86VB7
4261 ENSG00000179583 CIITA Q29704
27010 ENSG00000196511 TPK1 Q9H3S4
140 ENSG00000282608 ADORA3 P0DMS8

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
PF-04691502PIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
BGT-226PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
SONOLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor22
VOXTALISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor21
BMS-986142BTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
HM-71224BTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor10
PICLIDENOSONADORA3Small moleculeAGONISTAdenosine A3 receptor agonist30
APITOLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
DS-7423PIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor10
L19IL2FN1AntibodyBINDING AGENTFibronectin binding agent30
MSC-2364447BTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor10
PAXALISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor22
AS-1409FN1AntibodyBINDING AGENTFibronectin binding agent10
PICTILISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
PF-06651600BTKSmall moleculeINHIBITORTEC family kinase inhibitor30
ABIVERTINIBBTKSmall moleculeINHIBITOREpidermal growth factor receptor erbB1 inhibitor30
ABIVERTINIB MALEATEEGFRSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
CAFFEINE, CITRATEDADORA1Small moleculeANTAGONISTAdenosine receptor antagonist40
VS-5584PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
SAMOTOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
L19TNFAFN1AntibodyBINDING AGENTFibronectin binding agent20
DACTOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor30
GNF-Pf-5468PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
WX-037PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
RILZABRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
SPEBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
PILARALISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor21
TASELISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor30
L19SIP 131IFN1AntibodyOTHERFibronectin other20
IBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor41
GEDATOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
OMIPALISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor10
ZANUBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor40
EVOBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
OTLERTUZUMABCD37AntibodyBINDING AGENTLeukocyte antigen CD37 binding agent10
BI-836826CD37UnknownINHIBITORLeukocyte antigen CD37 inhibitor20
CAFFEINEADORA1Small moleculeANTAGONISTAdenosine receptor antagonist40
SPEBRUTINIB BESYLATEBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
POSELTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
ADENOSINEADORA1Small moleculeAGONISTAdenosine receptor agonist40
PIRTOBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
OCRIPLASMINLAMA2EnzymePROTEOLYTIC ENZYMEFibronectin proteolytic enzyme40
ACALABRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor41
OXTRIPHYLLINEPDE4ASmall moleculeINHIBITORPhosphodiesterase 3 inhibitor40
ELSUBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
BRANEBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
NAMODENOSONADORA3Small moleculeAGONISTAdenosine A3 receptor agonist20
PA-799PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
TIRABRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor20
FENEBRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
GSK-1059615PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
BUPARLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor32
NARATUXIMAB EMTANSINECD37AntibodyBINDING AGENTLeukocyte antigen CD37 binding agent10
THEOPHYLLINEADORA1Small moleculeINHIBITORPhosphodiesterase 3 inhibitor40
SF-1126PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
ORELABRUTINIBBTKSmall moleculeINHIBITORTyrosine-protein kinase BTK inhibitor30
AMINOPHYLLINEPDE3ASmall moleculeINHIBITORPhosphodiesterase 3 inhibitor40
PANULISIBACVRL1Small moleculeINHIBITORSerine/threonine-protein kinase receptor R3 inhibitor10
NELFINAVIRABCB1Small moleculeSUBSTRATE/INDUCER/INHIBITOREnergy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells, drugbank00

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-97

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-00740DNAH5down-regulatesTHRArepressesR-97111Drugs (59)
CMF-04213RBPJLdown-regulatesTHRArepressesR-97115Drugs (59)
CMF-10046ATP8A2up-regulatesTHRArepressesR-97112Drugs (59)
CMF-17972PRPF40Bup-regulatesTHRArepressesR-97113Drugs (59)
CMF-18136SGIP1down-regulatesTHRArepressesR-97112Drugs (59)
CMF-19288NF1down-regulatesTHRArepressesR-97116Drugs (59)
CMF-21635MUC17down-regulatesTHRArepressesR-97116Drugs (59)
CMF-21893PRAMEdown-regulatesTHRArepressesR-97113Drugs (59)
CMF-26582NAALADL1down-regulatesTHRArepressesR-97114Drugs (59)
CMF-30617SALL4up-regulatesTHRArepressesR-97113Drugs (59)
CMF-35043FGFR3down-regulateshsa-mir-454-3prepressesR-973129Drugs (59)
CMF-35075FGFR3down-regulateshsa-mir-20brepressesR-974426Drugs (59)
CMF-35967AHNAK2up-regulateshsa-mir-106brepressesR-972116Drugs (59)
CMF-35988AHNAK2up-regulateshsa-mir-93repressesR-974426Drugs (59)
CMF-36016AHNAK2up-regulateshsa-mir-20brepressesR-974426Drugs (59)
CMF-36136TNK2up-regulateshsa-mir-17-3prepressesR-975240Drugs (59)
CMF-36682ATP8A2up-regulateshsa-mir-454-3prepressesR-973127Drugs (59)
CMF-36712ATP8A2up-regulateshsa-mir-17-3prepressesR-975240Drugs (59)
CMF-36751ATP8A2up-regulateshsa-mir-93repressesR-974432Drugs (59)
CMF-36785ATP8A2up-regulateshsa-mir-20brepressesR-974431Drugs (59)
CMF-37679ADAMTS8up-regulateshsa-mir-17-3prepressesR-975240Drugs (59)
CMF-38080OR51F1up-regulateshsa-mir-106brepressesR-972117Drugs (59)
CMF-38097OR51F1up-regulateshsa-mir-93repressesR-974435Drugs (59)
CMF-38314ZNF845up-regulateshsa-mir-454-3prepressesR-973127Drugs (59)
CMF-38419KCNB2down-regulateshsa-mir-106brepressesR-972115Drugs (59)
CMF-38434KCNB2down-regulateshsa-mir-17-3prepressesR-975236Drugs (59)
CMF-38470KCNB2down-regulateshsa-mir-93repressesR-974427Drugs (59)
CMF-38979SGIP1down-regulateshsa-mir-17-3prepressesR-975226Drugs (59)
CMF-39006SGIP1down-regulateshsa-mir-93repressesR-974423Drugs (59)
CMF-39029SGIP1down-regulateshsa-mir-20brepressesR-974423Drugs (59)
CMF-39124DNMBPdown-regulateshsa-mir-17-3prepressesR-975235Drugs (59)
CMF-39552NF1down-regulateshsa-mir-106brepressesR-972120Drugs (59)
CMF-39619NF1down-regulateshsa-mir-93repressesR-974431Drugs (59)
CMF-39709NF1down-regulateshsa-mir-20brepressesR-974431Drugs (59)
CMF-39754RPSAP58down-regulateshsa-mir-17-3prepressesR-975240Drugs (59)
CMF-39810UGT2B4down-regulateshsa-mir-149repressesR-975135Drugs (59)
CMF-39923TDRD9down-regulateshsa-mir-106brepressesR-972121Drugs (59)
CMF-39945TDRD9down-regulateshsa-mir-17-3prepressesR-975242Drugs (59)
CMF-41316TP53up-regulateshsa-mir-17-3prepressesR-975252Drugs (59)
CMF-41368TP53up-regulateshsa-mir-93repressesR-974444Drugs (59)
CMF-41529TP53up-regulateshsa-mir-20brepressesR-974444Drugs (59)
CMF-41770IQSEC3up-regulateshsa-mir-454-3prepressesR-973125Drugs (59)
CMF-41898IQSEC3up-regulateshsa-mir-20brepressesR-974434Drugs (59)
CMF-43290POLRMTdown-regulateshsa-mir-17-3prepressesR-97529Drugs (59)