Regulon: R-3226
Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.
Regulon Summary
Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.
| Genes | Cox Hazard Ratio | Regulators | Causal Flows | Transcriptional Programs | Hallmarks |
|---|---|---|---|---|---|
| 8 | -2.15526 | 1 | 2 | Pr-120 |           |
Regulon Genes
List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.
| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 6683 | ENSG00000021574 | SPAST | E5KRP5 |
| 10203 | ENSG00000064989 | CALCRL | Q16602 |
| 50999 | ENSG00000117500 | TMED5 | Q9Y3A6 |
| 54453 | ENSG00000132669 | RIN2 | Q8WYP3 |
| 55213 | ENSG00000136144 | RCBTB1 | Q8NDN9 |
| 5783 | ENSG00000163629 | PTPN13 | Q12923 |
| 4082 | ENSG00000277443 | MARCKS | P29966 |
| 11056 | ENSG00000278053 | DDX52 | A0A087X069 |
Regulon Drugs
| Name | Approved Symbol | Type | Action Type | Mechanism of Action | Max Trial Phase | Max GBM Phase |
|---|---|---|---|---|---|---|
| RIMEGEPANT SULFATE | CALCRL | Small molecule | ANTAGONIST | Calcitonin gene-related peptide type 1 receptor antagonist | 4 | 0 |
| TELCAGEPANT | CALCRL | Small molecule | ANTAGONIST | Calcitonin gene-related peptide type 1 receptor antagonist | 3 | 0 |
| ATOGEPANT | CALCRL | Small molecule | ANTAGONIST | Calcitonin gene-related peptide type 1 receptor antagonist | 4 | 0 |
| UBROGEPANT | CALCRL | Small molecule | ANTAGONIST | Calcitonin gene-related peptide type 1 receptor antagonist | 4 | 0 |
| ERENUMAB | CALCRL | Antibody | ANTAGONIST | Calcitonin gene-related peptide type 1 receptor antagonist | 4 | 0 |
| RIMEGEPANT | CALCRL | Small molecule | ANTAGONIST | Calcitonin gene-related peptide type 1 receptor antagonist | 4 | 0 |
| BI-44370 | CALCRL | Small molecule | ANTAGONIST | Calcitonin gene-related peptide type 1 receptor antagonist | 2 | 0 |
| MK3207 | CALCRL | Small molecule | ANTAGONIST | Calcitonin gene-related peptide type 1 receptor antagonist | 2 | 0 |
| DAVALINTIDE | RAMP1 | Protein | AGONIST | Calcitonin gene-related peptide type 1 receptor agonist | 2 | 0 |
| OLCEGEPANT | CALCRL | Small molecule | ANTAGONIST | Calcitonin gene-related peptide type 1 receptor antagonist | 2 | 0 |
Causal Flows
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows for Regulon R-3226
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-13009 | GLT1D1 | up-regulates | PHOX2A | represses | R-3226 | 5 | 1 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)RIMEGEPANT SULFATE, TELCAGEPANT, ATOGEPANT, UBROGEPANT, ERENUMAB, RIMEGEPANT, BI-44370, MK3207, DAVALINTIDE, OLCEGEPANT |
| CMF-25893 | PIK3CA | down-regulates | PHOX2A | represses | R-3226 | 5 | 1 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)RIMEGEPANT SULFATE, TELCAGEPANT, ATOGEPANT, UBROGEPANT, ERENUMAB, RIMEGEPANT, BI-44370, MK3207, DAVALINTIDE, OLCEGEPANT |