Regulon

Regulon: R-1942

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
18	2.78735	1	12	Pr-43

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
9902	ENSG00000011028	MRC2	Q9UBG0
6717	ENSG00000075142	SRI	P30626
760	ENSG00000104267	CA2	P00918
8985	ENSG00000106397	PLOD3	O60568
1647	ENSG00000116717	GADD45A	P24522
1266	ENSG00000117519	CNN3	Q15417
5322	ENSG00000127472	PLA2G5	P39877
2012	ENSG00000134531	EMP1	P54849
967	ENSG00000135404	CD63	P08962
389	ENSG00000155366	RHOC	E9PLA2
8324	ENSG00000155760	FZD7	O75084
1140	ENSG00000170175	CHRNB1	P11230
114897	ENSG00000173918	C1QTNF1	Q9BXJ1
1466	ENSG00000175183	CSRP2	Q16527
56674	ENSG00000175348	TMEM9B	Q9NQ34
24147	ENSG00000179431	FJX1	Q86VR8
25840	ENSG00000185432	METTL7A	A0A024R118
3269	ENSG00000196639	HRH1	P35367

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase
CISATRACURIUM	CHRNA1	Small molecule	ANTAGONIST	Muscle-type nicotinic acetylcholine receptor antagonist	4
PROMETHAZINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TRIPROLIDINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
LEVOCETIRIZINE DIHYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
KETOTIFEN FUMARATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
PYRILAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TRIPELENNAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
RUPATADINE	PTAFR	Small molecule	ANTAGONIST	Platelet activating factor receptor antagonist	3
DOXYLAMINE SUCCINATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CISATRACURIUM BESYLATE	CHRNA1	Small molecule	ANTAGONIST	Muscle-type nicotinic acetylcholine receptor antagonist	4
MECLIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BEPOTASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BROMPHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CLEMASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
OLOPATADINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
SUXAMETHONIUM	CHRNA1	Small molecule	AGONIST	Muscle-type nicotinic acetylcholine receptor agonist	4
CYPROHEPTADINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BRINZOLAMIDE	CA2	Small molecule	INHIBITOR	Carbonic anhydrase II inhibitor	4
EPINASTINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TERFENADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CARBINOXAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DEXCHLORPHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ORPHENADRINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4
CHLORPHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DORZOLAMIDE HYDROCHLORIDE	CA2	Small molecule	INHIBITOR	Carbonic anhydrase II inhibitor	4
DICHLORPHENAMIDE	CA4	Small molecule	INHIBITOR	Carbonic anhydrase IV inhibitor	4
DEXBROMPHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
OLOPATADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ASTEMIZOLE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CHLORPHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
HISTAMINE	HRH1	Small molecule	AGONIST	Histamine H1 receptor agonist	4
LEVOCABASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DEXBROMPHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
MIVACURIUM	CHRNA1	Small molecule	ANTAGONIST	Muscle-type nicotinic acetylcholine receptor antagonist	4
EBASTINE	HRH1	Small molecule	INVERSE AGONIST	Histamine H1 receptor inverse agonist	3
SULTHIAME	CA2	Small molecule	INHIBITOR	Carbonic anhydrase inhibitor	4
CINNARIZINE	HRH1	Small molecule	BLOCKER	Voltage-gated L-type calcium channel blocker	4
VARESPLADIB METHYL	PLA2G5	Small molecule	INHIBITOR	Group X secretory phospholipase A2 inhibitor	3
HYDROXYZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
LORATADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DORZOLAMIDE	CA2	Small molecule	INHIBITOR	Carbonic anhydrase II inhibitor	4
LY2624803	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	2
ROCURONIUM BROMIDE	CHRNA1	Small molecule	ANTAGONIST	Muscle-type nicotinic acetylcholine receptor antagonist	4
PHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ACETAZOLAMIDE	CA4	Small molecule	INHIBITOR	Carbonic anhydrase XII inhibitor	4
TRIPROLIDINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
METHAZOLAMIDE	CA2	Small molecule	INHIBITOR	Carbonic anhydrase II inhibitor	4
MIVACURIUM CHLORIDE	CHRNA1	Small molecule	ANTAGONIST	Muscle-type nicotinic acetylcholine receptor antagonist	4
DIPHENHYDRAMINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TRIMIPRAMINE	SLC6A2	Small molecule	INHIBITOR	Norepinephrine transporter inhibitor	4
BUCLIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
EPINASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ORPHENADRINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4
KETOTIFEN	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
FEXOFENADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BILASTINE	HRH1	Small molecule	INVERSE AGONIST	Histamine H1 receptor inverse agonist	4
CHLORPHENOXAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
LEVOCABASTINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIBENZEPIN	HRH1	Small molecule	INHIBITOR	Norepinephrine transporter inhibitor	4
PROMETHAZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
AZELASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIPHENHYDRAMINE CITRATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TOLAZOLINE	HRH1	Small molecule	ANTAGONIST	Adrenergic receptor alpha antagonist	4
METHYLPROMAZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
AZELASTINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ANTAZOLINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CYCLIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
FEXOFENADINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DOXYLAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CETIRIZINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIPHENYLPYRALINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ESMIRTAZAPINE MALEATE	ADRA2B	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	3
LEVOCETIRIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ACRIVASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
BEPOTASTINE BESYLATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIPHENHYDRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
THENALIDINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIMENHYDRINATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
GSK-1004723	HRH1	Small molecule	ANTAGONIST	Histamine H3 receptor antagonist	2
PYRILAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ORPHENADRINE CITRATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4
DEXCHLORPHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CYPROHEPTADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
PHENIRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
CLEMASTINE FUMARATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
TOPIRAMATE	CA4	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4
VANTICTUMAB	FZD5	Antibody	ANTAGONIST	Frizzled-1 antagonist	1
BROMODIPHENHYDRAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DIMETHINDENE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
AZATADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ESMIRTAZAPINE	ADRA2B	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	3
BROMPHENIRAMINE MALEATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
MECLIZINE HYDROCHLORIDE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
METHAPYRILENE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
EMEDASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
MIZOLASTINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
HYDROXYZINE PAMOATE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ALCAFTADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
ACETAZOLAMIDE SODIUM	CA4	Small molecule	INHIBITOR	Carbonic anhydrase XII inhibitor	4
BETAHISTINE	HRH1	Small molecule	AGONIST	Histamine H1 receptor agonist	4
CARBINOXAMINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
DESLORATADINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
POLMACOXIB	PTGS2	Small molecule	INHIBITOR	Carbonic anhydrase I inhibitor	3
ROCURONIUM	CHRNA1	Small molecule	ANTAGONIST	Muscle-type nicotinic acetylcholine receptor antagonist	4
CETIRIZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4
METHDILAZINE	HRH1	Small molecule	ANTAGONIST	Histamine H1 receptor antagonist	4

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1942

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-04153	ESPNP	up-regulates	RORA	activates	R-1942	8	1	Drugs (106) Regulator Drugs (0) Regulon Drugs (106) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, VARESPLADIB METHYL, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE
CMF-04395	ATP8B3	up-regulates	RORA	activates	R-1942	8	2	Drugs (106) Regulator Drugs (0) Regulon Drugs (106) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, VARESPLADIB METHYL, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE
CMF-04835	NEFM	up-regulates	RORA	activates	R-1942	8	3	Drugs (106) Regulator Drugs (0) Regulon Drugs (106) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, VARESPLADIB METHYL, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE
CMF-04909	ABCC5	down-regulates	RORA	activates	R-1942	8	2	Drugs (106) Regulator Drugs (0) Regulon Drugs (106) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, VARESPLADIB METHYL, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE
CMF-05274	PCSK6	up-regulates	RORA	activates	R-1942	8	2	Drugs (106) Regulator Drugs (0) Regulon Drugs (106) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, VARESPLADIB METHYL, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE
CMF-09607	OR9G9	up-regulates	RORA	activates	R-1942	8	2	Drugs (106) Regulator Drugs (0) Regulon Drugs (106) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, VARESPLADIB METHYL, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE
CMF-11192	NRK	up-regulates	RORA	activates	R-1942	8	2	Drugs (106) Regulator Drugs (0) Regulon Drugs (106) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, VARESPLADIB METHYL, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE
CMF-11256	OR5W2	up-regulates	RORA	activates	R-1942	8	4	Drugs (106) Regulator Drugs (0) Regulon Drugs (106) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, VARESPLADIB METHYL, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE
CMF-16187	USP11	down-regulates	RORA	activates	R-1942	8	2	Drugs (106) Regulator Drugs (0) Regulon Drugs (106) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, VARESPLADIB METHYL, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE
CMF-16389	SUSD5	up-regulates	RORA	activates	R-1942	8	4	Drugs (106) Regulator Drugs (0) Regulon Drugs (106) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, VARESPLADIB METHYL, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE
CMF-24467	SEMA3C	down-regulates	RORA	activates	R-1942	8	5	Drugs (106) Regulator Drugs (0) Regulon Drugs (106) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, VARESPLADIB METHYL, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE
CMF-24786	HIST1H2BE	up-regulates	RORA	activates	R-1942	8	4	Drugs (106) Regulator Drugs (0) Regulon Drugs (106) CISATRACURIUM, PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, CISATRACURIUM BESYLATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, SUXAMETHONIUM, CYPROHEPTADINE HYDROCHLORIDE, BRINZOLAMIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, DORZOLAMIDE HYDROCHLORIDE, DICHLORPHENAMIDE, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, MIVACURIUM, EBASTINE, SULTHIAME, CINNARIZINE, VARESPLADIB METHYL, HYDROXYZINE, LORATADINE, DORZOLAMIDE, LY2624803, ROCURONIUM BROMIDE, PHENIRAMINE MALEATE, ACETAZOLAMIDE, TRIPROLIDINE HYDROCHLORIDE, METHAZOLAMIDE, MIVACURIUM CHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, TOPIRAMATE, VANTICTUMAB, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, ACETAZOLAMIDE SODIUM, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, POLMACOXIB, ROCURONIUM, CETIRIZINE, METHDILAZINE

Regulon: R-1942

Regulon Summary

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Causal Mechanistic Flows for Regulon R-1942

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