Regulon

Regulon: R-1925

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
182.8910911Pr-0Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
9168 ENSG00000034510 TMSB10 P63313
841 ENSG00000064012 CASP8 Q14790
3385 ENSG00000076662 ICAM3 P32942
966 ENSG00000085063 CD59 P13987
3956 ENSG00000100097 LGALS1 P09382
7076 ENSG00000102265 TIMP1 Q6FGX5
27286 ENSG00000102359 SRPX2 O60687
5216 ENSG00000108518 PFN1 P07737
7045 ENSG00000120708 TGFBI Q15582
813 ENSG00000128595 CALU O43852
4060 ENSG00000139329 LUM P51884
831 ENSG00000153113 CAST P20810
5937 ENSG00000153250 RBMS1 P29558
840 ENSG00000165806 CASP7 P55210
307 ENSG00000196975 ANXA4 Q6P452
375035 ENSG00000213064 SFT2D2 O95562
7106 ENSG00000214063 TSPAN4 O14817
123803 ENSG00000275779 NTAN1 H3BNJ5

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
DAVANATLGALS3UnknownINHIBITORGalectin-1 inhibitor20
NIVOCASANCASP1Small moleculeINHIBITORCaspase-9 inhibitor20
EMRICASANCASP4Small moleculeINHIBITORCaspase inhibitor20

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1925

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-03495SLC4A10up-regulatesHBP1activatesR-1925123Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

DAVANAT, NIVOCASAN, EMRICASAN