Regulon

Regulon: R-1760

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
6	2.56489	1	5	Pr-5

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
5743	ENSG00000073756	PTGS2	P35354
2355	ENSG00000075426	FOSL2	P15408
857	ENSG00000105974	CAV1	A0A024R757
53918	ENSG00000152684	PELO	Q9BRX2
1836	ENSG00000155850	SLC26A2	P50443
5271	ENSG00000166401	SERPINB8	A0A024R2B1

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
IBUPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	2
PIRPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
PHENYLBUTAZONE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
CIMICOXIB	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	2	0
ACETAMINOPHEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	2
OXYPHENBUTAZONE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
CELECOXIB	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	4	2
MELOXICAM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	4	0
BROMFENAC SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
ACECLOFENAC	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	4	0
OLSALAZINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
LORNOXICAM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
FLURBIPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
DIPYRONE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
FENOPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
APRICOXIB	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	2	0
NAPROXEN SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
DEXKETOPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
PARECOXIB	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	4	0
ASPIRIN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	2
ESFLURBIPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	3	0
ALOXIPRIN	PTGS2	Unknown	INHIBITOR	Cyclooxygenase inhibitor	4	0
ETORICOXIB	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	4	0
INDOPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
KETOROLAC	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
INDOMETHACIN SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
BENZYDAMINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
LUMIRACOXIB	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	4	0
NAPROXEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
DICLOFENAC EPOLAMINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
FENOPROFEN CALCIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
MECLOFENAMIC ACID	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
OLSALAZINE SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
APAZONE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
NABUMETONE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	4	0
ROFECOXIB	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	4	0
MESALAMINE	PPARG	Small molecule	AGONIST	Peroxisome proliferator-activated receptor gamma agonist	4	0
ACEMETACIN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
PARECOXIB SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	4	0
IBUPROFEN SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
BALSALAZIDE DISODIUM	PPARG	Small molecule	INHIBITOR	Arachidonate 5-lipoxygenase inhibitor	4	0
NEPAFENAC	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
DICLOFENAC POTASSIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
IBUPROFEN LYSINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
PIROXICAM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
ETODOLAC	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	4	0
SUPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
SULFASALAZINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	1
MECLOFENAMATE SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
GW-406381	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	3	0
LOXOPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	3	0
DICLOFENAC SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
BENZYDAMINE HYDROCHLORIDE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
TOLMETIN SODIUM	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
KETOROLAC TROMETHAMINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
DEXIBUPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
SULINDAC	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
KETOPROFEN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
BALSALAZIDE	PPARG	Small molecule	INHIBITOR	Arachidonate 5-lipoxygenase inhibitor	4	0
NAPROXCINOD	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	3	0
TOLMETIN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
DICLOFENAC	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
BISMUTH SUBSALICYLATE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
MEFENAMIC ACID	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
GLAFENINE	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
DIFLUNISAL	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
BROMFENAC	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
NAPROXEN ETEMESIL	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	2	0
INDOMETHACIN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
OXAPROZIN	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase inhibitor	4	0
IGURATIMOD	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	3	0
VALDECOXIB	PTGS2	Small molecule	INHIBITOR	Cyclooxygenase-2 inhibitor	4	0
POLMACOXIB	PTGS2	Small molecule	INHIBITOR	Carbonic anhydrase I inhibitor	3	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1760

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-01848	TMPRSS15	down-regulates	ZNF232	represses	R-1760	5	2	Drugs (73) Regulator Drugs (0) Regulon Drugs (73) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, MELOXICAM, BROMFENAC SODIUM, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB
CMF-12375	GPR98	up-regulates	ZNF232	represses	R-1760	5	1	Drugs (73) Regulator Drugs (0) Regulon Drugs (73) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, MELOXICAM, BROMFENAC SODIUM, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB
CMF-19595	NF1	down-regulates	ZNF232	represses	R-1760	5	4	Drugs (73) Regulator Drugs (0) Regulon Drugs (73) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, MELOXICAM, BROMFENAC SODIUM, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB
CMF-19687	RPSAP58	down-regulates	ZNF232	represses	R-1760	5	2	Drugs (73) Regulator Drugs (0) Regulon Drugs (73) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, MELOXICAM, BROMFENAC SODIUM, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB
CMF-25962	C10orf12	up-regulates	ZNF232	represses	R-1760	5	1	Drugs (73) Regulator Drugs (0) Regulon Drugs (73) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, MELOXICAM, BROMFENAC SODIUM, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB

Regulon: R-1760

Regulon Summary

Regulon Genes

Regulon Drugs

Causal Flows

Causal Mechanistic Flows for Regulon R-1760

Regulator Drugs (0)

Regulon Drugs (73)

Regulator Drugs (0)

Regulon Drugs (73)

Regulator Drugs (0)

Regulon Drugs (73)

Regulator Drugs (0)

Regulon Drugs (73)

Regulator Drugs (0)

Regulon Drugs (73)