Pr-94
Genes (41)
IFRD1, TAX1BP1, BTN3A3, NFE2L2, ABHD3, ETFDH, SKAP2, ABCC9, LIPG, SMAD5, IMPACT, ADCYAP1R1, ENOX2, CYP51A1, RNF19A, ZMPSTE24, PHKB, NBN, BCL6, APPL2, KIAA1033, RDX, CDH11, HS2ST1, USP16, SPG20, GPM6B, TM7SF3, PMP22, DEGS1, PRMT2, AP1S2, DFNA5, 7-Sep, NDUFAF1, TRAF3IP2, ABHD4, RPE65, TSPAN3, RHOBTB3, PTTG1IPRegulons (14)
R-408, R-585, R-659, R-1043, R-1214, R-1315, R-1671, R-2026, R-2443, R-2486, R-2583, R-2740, R-3663, R-3772Regulons in program Pr-94
| Regulon | Cox Hazard Ratio | # genes | # causal flows |
|---|---|---|---|
| R-408 | 1.64328 | 6 | 3 |
| R-585 | 1.93678 | 11 | 10 |
| R-659 | 1.92471 | 12 | 18 |
| R-1043 | -0.118116 | 12 | 13 |
| R-1214 | 1.87512 | 8 | 7 |
| R-1315 | 1.41368 | 8 | 8 |
| R-1671 | 2.07036 | 7 | 6 |
| R-2026 | 1.79457 | 10 | 23 |
| R-2443 | 1.82272 | 9 | 14 |
| R-2486 | 2.2191 | 8 | 10 |
| R-2583 | 1.9805 | 6 | 19 |
| R-2740 | 1.8749 | 7 | 16 |
| R-3663 | -0.470983 | 6 | 4 |
| R-3772 | 2.51777 | 5 | 17 |
Genes in program Pr-94
Causal Mechanistic Flows with Program Pr-94
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-02035 | TCHH | down-regulates | FOXD2 | represses | R-2583 | 6 | 3 | Drugs (1) |
| CMF-03906 | DSP | down-regulates | FOXD2 | represses | R-2583 | 6 | 6 | Drugs (1) |
| CMF-03997 | DSP | down-regulates | IRF4 | represses | R-3772 | 5 | 2 | Drugs (1) |
| CMF-04165 | ESPNP | down-regulates | FOXD2 | represses | R-2583 | 6 | 2 | Drugs (1) |
| CMF-04851 | NEFM | down-regulates | HOXD9 | represses | R-1671 | 5 | 2 | Drugs (1) |
| CMF-04861 | NEFM | down-regulates | FOXD2 | represses | R-2583 | 6 | 1 | Drugs (1) |
| CMF-04913 | ABCC5 | down-regulates | IRF7 | activates | R-2486 | 21 | 9 | Drugs (1) |
| CMF-05321 | PCSK6 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-06231 | GABRB2 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-06562 | STAG2 | down-regulates | FOXD2 | represses | R-2583 | 6 | 2 | Drugs (1) |
| CMF-06790 | ATRX | down-regulates | IRF7 | activates | R-2486 | 21 | 19 | Drugs (1) |
| CMF-07764 | LZTR1 | down-regulates | FOXD2 | represses | R-2583 | 6 | 1 | Drugs (1) |
| CMF-08842 | FBLN2 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-09384 | CUL1 | down-regulates | IRF4 | represses | R-3772 | 5 | 2 | Drugs (1) |
| CMF-11168 | DGKD | down-regulates | IRF7 | activates | R-2486 | 21 | 4 | Drugs (1) |
| CMF-11270 | OR5W2 | down-regulates | IRF4 | represses | R-3772 | 5 | 2 | Drugs (1) |
| CMF-11588 | FNDC3B | down-regulates | FOXD2 | represses | R-2583 | 6 | 2 | Drugs (1) |
| CMF-11607 | DBR1 | down-regulates | FOXD2 | represses | R-2583 | 6 | 1 | Drugs (1) |
| CMF-12510 | LAMB3 | down-regulates | FOXD2 | represses | R-2583 | 6 | 2 | Drugs (1) |
| CMF-14155 | CD1D | down-regulates | FOXD2 | represses | R-2583 | 6 | 2 | Drugs (1) |
| CMF-14833 | CALCR | down-regulates | FOXD2 | represses | R-2583 | 6 | 4 | Drugs (1) |
| CMF-14927 | SDHAP3 | down-regulates | FOXD2 | represses | R-2583 | 6 | 2 | Drugs (1) |
| CMF-14948 | SDHAP3 | down-regulates | IRF4 | represses | R-3772 | 5 | 3 | Drugs (1) |
| CMF-15428 | DSE | down-regulates | FOXD2 | represses | R-2583 | 6 | 6 | Drugs (1) |
| CMF-15789 | GRM3 | up-regulates | IRF7 | activates | R-2486 | 21 | 7 | Drugs (1) |
| CMF-15799 | GRM3 | down-regulates | HOXD9 | represses | R-1671 | 5 | 2 | Drugs (1) |
| CMF-16227 | USP11 | up-regulates | HOXD9 | represses | R-1671 | 5 | 2 | Drugs (1) |
| CMF-16398 | SUSD5 | up-regulates | IRF7 | activates | R-2486 | 21 | 12 | Drugs (1) |
| CMF-16484 | SUSD5 | down-regulates | IRF4 | represses | R-3772 | 5 | 2 | Drugs (1) |
| CMF-16674 | DNAJC11 | down-regulates | FOXD2 | represses | R-2583 | 6 | 5 | Drugs (1) |
| CMF-17118 | RERE | down-regulates | IRF4 | represses | R-3772 | 5 | 3 | Drugs (1) |
| CMF-18700 | MPP7 | down-regulates | IRF7 | activates | R-2486 | 21 | 6 | Drugs (1) |
| CMF-18908 | TEAD1 | down-regulates | IRF7 | activates | R-2486 | 21 | 4 | Drugs (1) |
| CMF-20311 | FREM1 | down-regulates | FOXD2 | represses | R-2583 | 6 | 3 | Drugs (1) |
| CMF-21359 | GRIK3 | down-regulates | HOXD9 | represses | R-1671 | 5 | 2 | Drugs (1) |
| CMF-21906 | PRAME | down-regulates | FOXD2 | represses | R-2583 | 6 | 2 | Drugs (1) |
| CMF-21919 | PRAME | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-22429 | IDH1 | down-regulates | IRF7 | activates | R-2486 | 21 | 20 | Drugs (1) |
| CMF-23275 | RNF17 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-23426 | SPAG17 | down-regulates | FOXD2 | represses | R-2583 | 6 | 2 | Drugs (1) |
| CMF-24271 | SIM1 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-24345 | SMCHD1 | down-regulates | FOXD2 | represses | R-2583 | 6 | 2 | Drugs (1) |
| CMF-24492 | SEMA3C | up-regulates | HOXD9 | represses | R-1671 | 5 | 2 | Drugs (1) |
| CMF-25692 | MUC4 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-26642 | C5AR1 | down-regulates | FOXD2 | represses | R-2583 | 6 | 1 | Drugs (1) |
| CMF-27149 | SLC44A5 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-28619 | ARHGAP28 | up-regulates | IRF7 | activates | R-2486 | 21 | 1 | Drugs (1) |
| CMF-29038 | OR51T1 | down-regulates | IRF4 | represses | R-3772 | 5 | 2 | Drugs (1) |
| CMF-29416 | EPHA8 | up-regulates | IRF7 | activates | R-2486 | 21 | 6 | Drugs (1) |
| CMF-29789 | SLC5A7 | down-regulates | HOXD9 | represses | R-1671 | 5 | 1 | Drugs (1) |
| CMF-30840 | RYR1 | down-regulates | IRF4 | represses | R-3772 | 5 | 2 | Drugs (1) |
| CMF-34750 | ABCC5 | up-regulates | hsa-mir-139 | represses | R-1671 | 58 | 26 | Drugs (1) |
| CMF-34887 | PCSK6 | down-regulates | hsa-mir-139 | represses | R-1671 | 58 | 2 | Drugs (1) |
| CMF-34899 | KDELC2 | down-regulates | hsa-mir-139 | represses | R-1671 | 58 | 7 | Drugs (1) |
| CMF-35256 | ATRX | up-regulates | hsa-mir-139 | represses | R-1671 | 58 | 58 | Drugs (1) |
| CMF-39374 | UPF1 | down-regulates | hsa-mir-139 | represses | R-1671 | 58 | 13 | Drugs (1) |
| CMF-40071 | ADCY1 | down-regulates | hsa-mir-139 | represses | R-1671 | 58 | 1 | Drugs (1) |
| CMF-40500 | IDH1 | up-regulates | hsa-mir-139 | represses | R-1671 | 58 | 58 | Drugs (1) |
| CMF-41974 | PVRL4 | up-regulates | hsa-mir-139 | represses | R-1671 | 58 | 6 | Drugs (1) |
| CMF-43319 | BRWD3 | down-regulates | hsa-mir-139 | represses | R-1671 | 58 | 2 | Drugs (1) |
| CMF-33462 | TCR_SIGNALING_IN_NAIVE_CD4+_T_CELLS | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
CMFlow summary not available
Enrichment summary not available