Program – gbmMINER Portal

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Program – gbmMINER Portal

Program

Program Pr-67

Genes (11)

FRYL, MPDZ, SLC11A2, RAB30, NCOA2, DST, GOLIM4, YOD1, ZNF471, ITSN1, RIC8B

Regulons (11)

R-711, R-749, R-777, R-806, R-1246, R-1260, R-1577, R-1712, R-2850, R-2931, R-3721

Regulons in program Pr-67

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-711	-1.53165	10	9
R-749	-1.70247	10	20
R-777	-1.59208	9	8
R-806	-0.58509	7	15
R-1246	-0.504031	5	7
R-1260	-0.783145	6	15
R-1577	-1.59208	9	6
R-1712	-1.31334	7	15
R-2850	-1.18434	8	9
R-2931	-2.31603	7	17
R-3721	-1.55772	6	19

Genes in program Pr-67

EnsEMBL Id	Entrez Id	Preferred
ENSG00000075539	285527	FRYL
ENSG00000107186	8777	MPDZ
ENSG00000110911	4891	SLC11A2
ENSG00000137502	27314	RAB30
ENSG00000140396	10499	NCOA2
ENSG00000151914	667	DST
ENSG00000173905	27333	GOLIM4
ENSG00000180667	55432	YOD1
ENSG00000196263	57573	ZNF471
ENSG00000205726	6453	ITSN1
ENSG00000111785	55188	RIC8B

Causal Mechanistic Flows with Program Pr-67

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-01263	KRT37	down-regulates	LMX1B	represses	R-2931	11	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-02103	ABCA4	down-regulates	LMX1B	represses	R-2931	11	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-02818	MST1	down-regulates	LMX1B	represses	R-2931	11	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-03785	DSP	down-regulates	LMX1B	represses	R-2931	11	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04157	ESPNP	down-regulates	LMX1B	represses	R-2931	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-08428	COL17A1	down-regulates	LMX1B	represses	R-2931	11	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10140	EML2	down-regulates	LMX1B	represses	R-2931	11	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10625	ITIH5L	down-regulates	LMX1B	represses	R-2931	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10831	PKD1L2	down-regulates	LMX1B	represses	R-2931	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11820	GPX5	down-regulates	LMX1B	represses	R-2931	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-13166	SLC26A8	down-regulates	LMX1B	represses	R-2931	11	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15970	PRIC285	down-regulates	LMX1B	represses	R-2931	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20402	CUX2	down-regulates	LMX1B	represses	R-2931	11	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-23046	AOX1	down-regulates	LMX1B	represses	R-2931	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-26426	SPAG5	down-regulates	LMX1B	represses	R-2931	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-30351	MAGEB6	down-regulates	LMX1B	represses	R-2931	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-30444	KIAA1467	down-regulates	LMX1B	represses	R-2931	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)

CMFlow summary not available

Enrichment summary not available