Pr-165
Regulons in program Pr-165
| Regulon | Cox Hazard Ratio | # genes | # causal flows |
|---|---|---|---|
| R-339 | 1.60631 | 7 | 4 |
| R-409 | 2.54182 | 6 | 6 |
| R-410 | 2.15864 | 5 | 4 |
| R-859 | 2.0365 | 9 | 4 |
| R-1614 | 2.07157 | 9 | 5 |
| R-2134 | 2.31917 | 6 | 3 |
| R-2495 | 2.28063 | 5 | 23 |
| R-2952 | 1.54352 | 8 | 10 |
Genes in program Pr-165
| EnsEMBL Id | Entrez Id | Preferred |
|---|---|---|
| ENSG00000035720 | 26228 | STAP1 |
| ENSG00000078081 | 27074 | LAMP3 |
| ENSG00000089692 | 3902 | LAG3 |
| ENSG00000109943 | 56253 | CRTAM |
| ENSG00000121594 | 941 | CD80 |
| ENSG00000147394 | 7739 | ZNF185 |
| ENSG00000157601 | 4599 | MX1 |
| ENSG00000068079 | 3430 | IFI35 |
| ENSG00000111331 | 4940 | OAS3 |
| ENSG00000111335 | 4939 | OAS2 |
| ENSG00000115415 | 6772 | STAT1 |
| ENSG00000119917 | 3437 | IFIT3 |
| ENSG00000205413 | 54809 | SAMD9 |
| ENSG00000134321 | 91543 | RSAD2 |
| ENSG00000163568 | 9447 | AIM2 |
| ENSG00000026751 | 57823 | SLAMF7 |
| ENSG00000134028 | 27299 | ADAMDEC1 |
| ENSG00000081041 | 2920 | CXCL2 |
| ENSG00000163734 | 2921 | CXCL3 |
| ENSG00000258818 | 6038 | RNASE4 |
| ENSG00000263528 | 9641 | IKBKE |
| ENSG00000107201 | 23586 | DDX58 |
| ENSG00000142494 | 55244 | SLC47A1 |
Causal Mechanistic Flows with Program Pr-165
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-02704 | ABCA5 | up-regulates | IRF7 | activates | R-2495 | 21 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02875 | SRRM2 | up-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03241 | OBSCN | down-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03330 | C12orf63 | up-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05897 | MKRN3 | down-regulates | IRF7 | activates | R-2495 | 21 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06100 | FGFR3 | down-regulates | SOX11 | represses | R-859 | 19 | 3 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)ABATACEPT, TEBOTELIMAB, IERAMILIMAB, FIANLIMAB, BELATACEPT, GALIXIMAB, MK-4280, ELOTUZUMAB, AZINTUXIZUMAB VEDOTIN, RELATLIMAB |
| CMF-06540 | SETD2 | down-regulates | IRF8 | activates | R-409 | 18 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06606 | CACNA1D | up-regulates | ZEB1 | represses | R-2134 | 13 | 2 | Drugs (3) |
| CMF-06617 | CACNA1D | down-regulates | IRF8 | activates | R-410 | 18 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07512 | OR4N4 | down-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07591 | AHNAK2 | down-regulates | IRF8 | activates | R-410 | 18 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08170 | TESK1 | down-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08933 | DIAPH2 | down-regulates | IRF8 | activates | R-410 | 18 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08935 | DIAPH2 | down-regulates | IRF8 | activates | R-409 | 18 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09041 | PSD4 | down-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10366 | FGG | up-regulates | SOX11 | represses | R-859 | 19 | 3 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)ABATACEPT, TEBOTELIMAB, IERAMILIMAB, FIANLIMAB, BELATACEPT, GALIXIMAB, MK-4280, ELOTUZUMAB, AZINTUXIZUMAB VEDOTIN, RELATLIMAB |
| CMF-10833 | PKD1L2 | up-regulates | ZEB1 | represses | R-2134 | 13 | 4 | Drugs (3) |
| CMF-11170 | DGKD | down-regulates | IRF7 | activates | R-2495 | 21 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11231 | TJP3 | down-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12151 | TMEM132D | up-regulates | SOX11 | represses | R-859 | 19 | 3 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)ABATACEPT, TEBOTELIMAB, IERAMILIMAB, FIANLIMAB, BELATACEPT, GALIXIMAB, MK-4280, ELOTUZUMAB, AZINTUXIZUMAB VEDOTIN, RELATLIMAB |
| CMF-12989 | UGT3A2 | down-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13933 | HRH2 | down-regulates | SOX11 | represses | R-859 | 19 | 5 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)ABATACEPT, TEBOTELIMAB, IERAMILIMAB, FIANLIMAB, BELATACEPT, GALIXIMAB, MK-4280, ELOTUZUMAB, AZINTUXIZUMAB VEDOTIN, RELATLIMAB |
| CMF-15867 | ZNF845 | down-regulates | IRF8 | activates | R-409 | 18 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16406 | SUSD5 | up-regulates | IRF7 | activates | R-2495 | 21 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17525 | CNTNAP3 | up-regulates | IRF7 | activates | R-2495 | 21 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18910 | TEAD1 | down-regulates | IRF7 | activates | R-2495 | 21 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18927 | TEAD1 | down-regulates | IRF8 | activates | R-409 | 18 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23503 | CUBN | up-regulates | ZEB1 | represses | R-2134 | 13 | 3 | Drugs (3) |
| CMF-24736 | RABGEF1 | up-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28356 | LAMB1 | up-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28726 | POF1B | up-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29417 | EPHA8 | up-regulates | IRF7 | activates | R-2495 | 21 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30000 | CYP4F3 | down-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30775 | ZDBF2 | down-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-31183 | LRFN2 | down-regulates | IRF8 | activates | R-410 | 18 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-31749 | PDGFR_ALPHA_SIGNALING_PATHWAY | up-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-32906 | EPHA2_FORWARD_SIGNALING | up-regulates | IRF8 | activates | R-409 | 18 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-33255 | EPHRIN_B_REVERSE_SIGNALING | up-regulates | IRF8 | activates | R-409 | 18 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-33720 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2495 | 21 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |