Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
SPRY1 - sprouty RTK signaling antagonist 1
Function
Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 10252 | ENSG00000164056 | SPRY1 | O43609 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1036 | Pr-38 | 1 | 1 | 9 |
| R-1144 | Pr-38 | 1 | 1 | 19 |
| R-1301 | Pr-38 | 1 | 1 | 38 |
| R-1462 | Pr-38 | 1 | 1 | 3 |
| R-1568 | Pr-38 | 1 | 1 | 38 |
| R-1590 | Pr-38 | 1 | 1 | 22 |
| R-1736 | Pr-38 | 1 | 1 | 2 |
| R-1772 | Pr-38 | 1 | 1 | 26 |
| R-1830 | Pr-38 | 1 | 1 | 16 |
| R-1884 | Pr-38 | 1 | 1 | 7 |
| R-1938 | Pr-38 | 1 | 1 | 36 |
| R-1950 | Pr-43 | 1 | 1 | 45 |
| R-1996 | Pr-38 | 1 | 1 | 39 |
| R-2021 | Pr-38 | 1 | 1 | 69 |
| R-2086 | Pr-38 | 1 | 1 | 7 |
| R-2125 | Pr-38 | 1 | 1 | 27 |
| R-2159 | Pr-38 | 1 | 1 | 32 |
| R-2381 | Pr-40 | 1 | 1 | 11 |
| R-2383 | Pr-38 | 1 | 1 | 9 |
| R-2384 | Pr-38 | 1 | 1 | 16 |
| R-2416 | Pr-38 | 1 | 1 | 5 |
| R-2453 | Pr-38 | 1 | 1 | 20 |
| R-2499 | Pr-38 | 1 | 1 | 10 |
| R-2737 | Pr-38 | 1 | 1 | 42 |
| R-2743 | Pr-38 | 1 | 1 | 17 |
| R-2768 | Pr-38 | 1 | 1 | 6 |
| R-2801 | Pr-38 | 1 | 1 | 5 |
| R-2807 | Pr-38 | 1 | 1 | 5 |
| R-2816 | Pr-38 | 1 | 1 | 20 |
| R-2843 | Pr-38 | 1 | 1 | 36 |
| R-2861 | Pr-38 | 1 | 1 | 31 |
| R-2884 | Pr-38 | 1 | 1 | 33 |
| R-2944 | Pr-38 | 1 | 1 | 16 |
| R-462 | Pr-38 | 1 | 1 | 24 |
| R-575 | Pr-38 | 1 | 1 | 39 |
| R-600 | Pr-40 | 1 | 1 | 1 |
| R-625 | Pr-38 | 1 | 1 | 5 |
| R-650 | Pr-38 | 1 | 1 | 36 |
| R-698 | Pr-38 | 1 | 1 | 26 |
| R-759 | Pr-38 | 1 | 1 | 30 |
| R-968 | Pr-38 | 1 | 1 | 22 |
| R-993 | Pr-38 | 1 | 1 | 31 |