Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
SPRED2 - sprouty related EVH1 domain containing 2
Function
Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 200734 | ENSG00000198369 | SPRED2 | Q7Z698 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1205 | Pr-38 | 1 | 1 | 21 |
| R-1301 | Pr-38 | 1 | 1 | 38 |
| R-1590 | Pr-38 | 1 | 1 | 22 |
| R-1736 | Pr-38 | 1 | 1 | 2 |
| R-1772 | Pr-38 | 1 | 1 | 26 |
| R-1873 | Pr-38 | 1 | 1 | 27 |
| R-1875 | Pr-38 | 1 | 1 | 6 |
| R-1938 | Pr-38 | 1 | 1 | 36 |
| R-1967 | Pr-40 | 1 | 1 | 6 |
| R-1996 | Pr-38 | 1 | 1 | 39 |
| R-2021 | Pr-38 | 1 | 1 | 69 |
| R-2032 | Pr-38 | 1 | 1 | 54 |
| R-2125 | Pr-38 | 1 | 1 | 27 |
| R-2159 | Pr-38 | 1 | 1 | 32 |
| R-2370 | Pr-38 | 1 | 1 | 1 |
| R-2384 | Pr-38 | 1 | 1 | 16 |
| R-2394 | Pr-38 | 1 | 1 | 28 |
| R-2427 | Pr-40 | 1 | 1 | 19 |
| R-2453 | Pr-38 | 1 | 1 | 20 |
| R-2655 | Pr-38 | 1 | 1 | 5 |
| R-2670 | Pr-38 | 1 | 1 | 36 |
| R-2685 | Pr-38 | 1 | 1 | 42 |
| R-2737 | Pr-38 | 1 | 1 | 42 |
| R-2738 | Pr-38 | 1 | 1 | 21 |
| R-2756 | Pr-38 | 1 | 1 | 53 |
| R-2782 | Pr-38 | 1 | 1 | 64 |
| R-2816 | Pr-38 | 1 | 1 | 20 |
| R-2861 | Pr-38 | 1 | 1 | 31 |
| R-2884 | Pr-38 | 1 | 1 | 33 |
| R-2927 | Pr-38 | 1 | 1 | 38 |
| R-2962 | Pr-38 | 1 | 1 | 52 |
| R-417 | Pr-40 | 1 | 1 | 14 |
| R-650 | Pr-38 | 1 | 1 | 36 |
| R-698 | Pr-38 | 1 | 1 | 26 |
| R-871 | Pr-38 | 1 | 1 | 25 |
| R-968 | Pr-38 | 1 | 1 | 22 |