Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
RGS2 - regulator of G protein signaling 2
Function
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 5997 | ENSG00000116741 | RGS2 | P41220 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1102 | Pr-5 | 1 | 1 | 7 |
| R-1284 | Pr-5 | 1 | 1 | 7 |
| R-178 | Pr-5 | 1 | 1 | 6 |
| R-1907 | Pr-5 | 1 | 1 | 13 |
| R-1984 | Pr-21 | 1 | 1 | 8 |
| R-1999 | Pr-5 | 1 | 1 | 7 |
| R-2127 | Pr-5 | 1 | 1 | 2 |
| R-213 | Pr-5 | 1 | 1 | 8 |
| R-2281 | Pr-5 | 1 | 1 | 14 |
| R-2355 | Pr-5 | 1 | 1 | 4 |
| R-2590 | Pr-5 | 1 | 1 | 6 |
| R-2623 | Pr-5 | 1 | 1 | 8 |
| R-2688 | Pr-5 | 1 | 1 | 16 |
| R-2946 | Pr-5 | 1 | 1 | 10 |
| R-2961 | Pr-5 | 1 | 1 | 16 |
| R-3105 | Pr-5 | 1 | 1 | 7 |
| R-3162 | Pr-5 | 1 | 1 | 9 |
| R-3398 | Pr-21 | 1 | 1 | 5 |
| R-3548 | Pr-5 | 1 | 1 | 6 |
| R-376 | Pr-5 | 1 | 1 | 15 |
| R-466 | Pr-5 | 1 | 1 | 12 |