Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
PTPN6 - protein tyrosine phosphatase non-receptor type 6
Function
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 5777 | ENSG00000111679 | PTPN6 | P29350 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1358 | Pr-4 | 1 | 1 | 6 |
| R-1401 | Pr-4 | 1 | 1 | 5 |
| R-158 | Pr-7 | 1 | 1 | 59 |
| R-1592 | Pr-4 | 1 | 1 | 87 |
| R-1829 | Pr-4 | 1 | 1 | 83 |
| R-192 | Pr-7 | 1 | 1 | 74 |
| R-1926 | Pr-4 | 1 | 1 | 75 |
| R-203 | Pr-7 | 1 | 1 | 9 |
| R-207 | Pr-7 | 1 | 1 | 44 |
| R-2123 | Pr-4 | 1 | 1 | 85 |
| R-2161 | Pr-4 | 1 | 1 | 71 |
| R-2305 | Pr-4 | 1 | 1 | 12 |
| R-232 | Pr-7 | 1 | 1 | 77 |
| R-2412 | Pr-4 | 1 | 1 | 71 |
| R-2456 | Pr-4 | 1 | 1 | 3 |
| R-246 | Pr-7 | 1 | 1 | 78 |
| R-2767 | Pr-4 | 1 | 1 | 70 |
| R-290 | Pr-7 | 1 | 1 | 68 |
| R-2943 | Pr-4 | 1 | 1 | 14 |
| R-298 | Pr-4 | 1 | 1 | 11 |
| R-315 | Pr-7 | 1 | 1 | 25 |
| R-326 | Pr-7 | 1 | 1 | 29 |
| R-3345 | Pr-4 | 1 | 1 | 2 |
| R-3348 | Pr-4 | 1 | 1 | 104 |
| R-3377 | Pr-4 | 1 | 1 | 7 |
| R-370 | Pr-7 | 1 | 1 | 30 |
| R-371 | Pr-4 | 1 | 1 | 74 |
| R-438 | Pr-7 | 1 | 1 | 44 |
| R-737 | Pr-4 | 1 | 1 | 72 |
| R-93 | Pr-7 | 1 | 1 | 17 |