Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
NRP1 - neuropilin 1
Function
Isoform 2Binds VEGF-165 and may inhibit its binding to cells (PubMed:10748121, PubMed:26503042). May induce apoptosis by sequestering VEGF-165 (PubMed:10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 8829 | ENSG00000099250 | NRP1 | O14786 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1046 | Pr-1 | 1 | 1 | 2 |
| R-1073 | Pr-1 | 1 | 1 | 4 |
| R-112 | Pr-7 | 1 | 1 | 20 |
| R-1133 | Pr-1 | 1 | 1 | 8 |
| R-1170 | Pr-1 | 1 | 1 | 4 |
| R-12 | Pr-1 | 1 | 1 | 14 |
| R-1346 | Pr-1 | 1 | 1 | 12 |
| R-137 | Pr-7 | 1 | 1 | 22 |
| R-1651 | Pr-1 | 1 | 1 | 3 |
| R-173 | Pr-7 | 1 | 1 | 34 |
| R-1886 | Pr-1 | 1 | 1 | 5 |
| R-1912 | Pr-1 | 1 | 1 | 8 |
| R-2005 | Pr-1 | 1 | 1 | 13 |
| R-203 | Pr-7 | 1 | 1 | 9 |
| R-2053 | Pr-1 | 1 | 1 | 61 |
| R-2268 | Pr-1 | 1 | 1 | 5 |
| R-2309 | Pr-1 | 1 | 1 | 9 |
| R-2322 | Pr-1 | 1 | 1 | 6 |
| R-2543 | Pr-1 | 1 | 1 | 7 |
| R-257 | Pr-7 | 1 | 1 | 56 |
| R-2612 | Pr-1 | 1 | 1 | 8 |
| R-2620 | Pr-1 | 1 | 1 | 3 |
| R-2811 | Pr-1 | 1 | 1 | 5 |
| R-2954 | Pr-1 | 1 | 1 | 14 |
| R-3016 | Pr-1 | 1 | 1 | 21 |
| R-3037 | Pr-1 | 1 | 1 | 5 |
| R-3066 | Pr-1 | 1 | 1 | 6 |
| R-3107 | Pr-1 | 1 | 1 | 5 |
| R-315 | Pr-7 | 1 | 1 | 25 |
| R-3168 | Pr-1 | 1 | 1 | 5 |
| R-3264 | Pr-1 | 1 | 1 | 5 |
| R-3552 | Pr-1 | 1 | 1 | 6 |
| R-356 | Pr-7 | 1 | 1 | 57 |
| R-362 | Pr-1 | 1 | 1 | 8 |
| R-370 | Pr-7 | 1 | 1 | 30 |
| R-385 | Pr-1 | 1 | 1 | 15 |
| R-395 | Pr-7 | 1 | 1 | 44 |
| R-413 | Pr-7 | 1 | 1 | 23 |
| R-438 | Pr-7 | 1 | 1 | 44 |
| R-444 | Pr-7 | 1 | 1 | 6 |
| R-582 | Pr-1 | 1 | 1 | 6 |
| R-632 | Pr-1 | 1 | 1 | 10 |
| R-646 | Pr-140 | 1 | 1 | 51 |
| R-856 | Pr-1 | 1 | 1 | 6 |
| R-86 | Pr-7 | 1 | 1 | 62 |
| R-93 | Pr-7 | 1 | 1 | 17 |
| R-980 | Pr-1 | 1 | 1 | 6 |