Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
LGALS3 - galectin 3
Function
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 3958 | ENSG00000131981 | LGALS3 | P17931 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1042 | Pr-6 | 1 | 1 | 5 |
| R-142 | Pr-6 | 1 | 1 | 8 |
| R-1487 | Pr-6 | 1 | 1 | 11 |
| R-1525 | Pr-6 | 1 | 1 | 11 |
| R-1681 | Pr-6 | 1 | 1 | 12 |
| R-1834 | Pr-6 | 1 | 1 | 8 |
| R-1911 | Pr-6 | 1 | 1 | 6 |
| R-1936 | Pr-6 | 1 | 1 | 14 |
| R-1985 | Pr-6 | 1 | 1 | 23 |
| R-1992 | Pr-6 | 1 | 1 | 51 |
| R-2056 | Pr-6 | 1 | 1 | 12 |
| R-216 | Pr-6 | 1 | 1 | 17 |
| R-217 | Pr-6 | 1 | 1 | 11 |
| R-2195 | Pr-6 | 1 | 1 | 12 |
| R-2266 | Pr-6 | 1 | 1 | 5 |
| R-2342 | Pr-6 | 1 | 1 | 6 |
| R-2549 | Pr-6 | 1 | 1 | 9 |
| R-2761 | Pr-6 | 1 | 1 | 20 |
| R-300 | Pr-6 | 1 | 1 | 16 |
| R-3166 | Pr-6 | 1 | 1 | 11 |
| R-3174 | Pr-6 | 1 | 1 | 17 |
| R-3378 | Pr-6 | 1 | 1 | 5 |
| R-3550 | Pr-6 | 1 | 1 | 7 |
| R-379 | Pr-6 | 1 | 1 | 10 |
| R-450 | Pr-6 | 1 | 1 | 11 |
| R-629 | Pr-6 | 1 | 1 | 10 |
| R-649 | Pr-6 | 1 | 1 | 13 |
| R-671 | Pr-6 | 1 | 1 | 6 |
| R-704 | Pr-6 | 1 | 1 | 7 |