Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
IQGAP1 - IQ motif containing GTPase activating protein 1
Function
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 8826 | ENSG00000140575 | IQGAP1 | P46940 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1037 | Pr-131 | 1 | 1 | 7 |
| R-1067 | Pr-131 | 1 | 1 | 49 |
| R-1068 | Pr-0 | 1 | 1 | 4 |
| R-113 | Pr-138 | 1 | 1 | 10 |
| R-114 | Pr-0 | 1 | 1 | 12 |
| R-1300 | Pr-0 | 1 | 1 | 25 |
| R-1304 | Pr-131 | 1 | 1 | 22 |
| R-1448 | Pr-131 | 1 | 1 | 1 |
| R-1517 | Pr-0 | 1 | 1 | 10 |
| R-1521 | Pr-131 | 1 | 1 | 20 |
| R-160 | Pr-131 | 1 | 1 | 10 |
| R-1676 | Pr-0 | 1 | 1 | 13 |
| R-1699 | Pr-131 | 1 | 1 | 18 |
| R-175 | Pr-0 | 1 | 1 | 11 |
| R-177 | Pr-131 | 1 | 1 | 55 |
| R-1853 | Pr-131 | 1 | 1 | 35 |
| R-194 | Pr-131 | 1 | 1 | 5 |
| R-1945 | Pr-131 | 1 | 1 | 9 |
| R-209 | Pr-0 | 1 | 1 | 6 |
| R-2113 | Pr-0 | 1 | 1 | 5 |
| R-2348 | Pr-0 | 1 | 1 | 9 |
| R-2426 | Pr-137 | 1 | 1 | 92 |
| R-2451 | Pr-131 | 1 | 1 | 68 |
| R-2452 | Pr-0 | 1 | 1 | 3 |
| R-2509 | Pr-0 | 1 | 1 | 9 |
| R-2589 | Pr-0 | 1 | 1 | 4 |
| R-2671 | Pr-131 | 1 | 1 | 7 |
| R-2687 | Pr-0 | 1 | 1 | 14 |
| R-2883 | Pr-131 | 1 | 1 | 29 |
| R-2940 | Pr-12 | 1 | 1 | 75 |
| R-3013 | Pr-131 | 1 | 1 | 50 |
| R-3120 | Pr-0 | 1 | 1 | 8 |
| R-3133 | Pr-0 | 1 | 1 | 8 |
| R-3156 | Pr-0 | 1 | 1 | 5 |
| R-3449 | Pr-131 | 1 | 1 | 60 |
| R-3459 | Pr-131 | 1 | 1 | 56 |
| R-357 | Pr-0 | 1 | 1 | 8 |
| R-375 | Pr-0 | 1 | 1 | 9 |
| R-377 | Pr-131 | 1 | 1 | 22 |
| R-576 | Pr-131 | 1 | 1 | 41 |
| R-626 | Pr-131 | 1 | 1 | 52 |
| R-679 | Pr-131 | 1 | 1 | 63 |
| R-680 | Pr-133 | 1 | 1 | 12 |
| R-970 | Pr-131 | 1 | 1 | 56 |
| R-991 | Pr-0 | 1 | 1 | 7 |
| R-995 | Pr-131 | 1 | 1 | 19 |