Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
FAM46A - terminal nucleotidyltransferase 5A
Function
Cytoplasmic non-canonical poly(A) RNA polymerase that catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and participates in the cytoplasmic polyadenylation (PubMed:33882302). Polyadenylates mRNA encoding extracellular matrix constituents and other genes crucial for bone mineralization and during osteoblast mineralization, mainly focuses on ER-targeted mRNAs (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 55603 | ENSG00000112773 | FAM46A | Q96IP4 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1042 | Pr-6 | 1 | 1 | 5 |
| R-142 | Pr-6 | 1 | 1 | 8 |
| R-1487 | Pr-6 | 1 | 1 | 11 |
| R-1525 | Pr-6 | 1 | 1 | 11 |
| R-1681 | Pr-6 | 1 | 1 | 12 |
| R-1834 | Pr-6 | 1 | 1 | 8 |
| R-1911 | Pr-6 | 1 | 1 | 6 |
| R-1936 | Pr-6 | 1 | 1 | 14 |
| R-1985 | Pr-6 | 1 | 1 | 23 |
| R-2056 | Pr-6 | 1 | 1 | 12 |
| R-217 | Pr-6 | 1 | 1 | 11 |
| R-2266 | Pr-6 | 1 | 1 | 5 |
| R-2342 | Pr-6 | 1 | 1 | 6 |
| R-3166 | Pr-6 | 1 | 1 | 11 |
| R-3174 | Pr-6 | 1 | 1 | 17 |
| R-3550 | Pr-6 | 1 | 1 | 7 |
| R-379 | Pr-6 | 1 | 1 | 10 |
| R-629 | Pr-6 | 1 | 1 | 10 |
| R-649 | Pr-6 | 1 | 1 | 13 |
| R-671 | Pr-6 | 1 | 1 | 6 |
| R-704 | Pr-6 | 1 | 1 | 7 |