Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
CHRNA9 - cholinergic receptor nicotinic alpha 9 subunit
Function
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 55584 | ENSG00000174343 | CHRNA9 | Q9UGM1 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1568 | Pr-38 | 1 | 1 | 38 |
| R-159 | Pr-38 | 1 | 1 | 11 |
| R-1736 | Pr-38 | 1 | 1 | 2 |
| R-1830 | Pr-38 | 1 | 1 | 16 |
| R-1938 | Pr-38 | 1 | 1 | 36 |
| R-2021 | Pr-38 | 1 | 1 | 69 |
| R-2125 | Pr-38 | 1 | 1 | 27 |
| R-2159 | Pr-38 | 1 | 1 | 32 |
| R-2416 | Pr-38 | 1 | 1 | 5 |
| R-2670 | Pr-38 | 1 | 1 | 36 |
| R-2685 | Pr-38 | 1 | 1 | 42 |
| R-2745 | Pr-38 | 1 | 1 | 8 |
| R-2768 | Pr-38 | 1 | 1 | 6 |
| R-2814 | Pr-38 | 1 | 1 | 9 |
| R-2816 | Pr-38 | 1 | 1 | 20 |
| R-2843 | Pr-38 | 1 | 1 | 36 |
| R-2861 | Pr-38 | 1 | 1 | 31 |
| R-2884 | Pr-38 | 1 | 1 | 33 |
| R-2938 | Pr-38 | 1 | 1 | 1 |
| R-575 | Pr-38 | 1 | 1 | 39 |
| R-650 | Pr-38 | 1 | 1 | 36 |
| R-698 | Pr-38 | 1 | 1 | 26 |
| R-767 | Pr-38 | 1 | 1 | 3 |
| R-993 | Pr-38 | 1 | 1 | 31 |